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US 6,855,321 B1Granted
Polyepitope carrier protein
AssigneeChiron Corporation
InventorsRino Rappuoli, Guido Grandi
Life of this patent
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Abstract
The invention relates to polyepitope carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are use useful as components of vaccines that can elicit a T-cell dependent immune response. These vaccines arm particularly useful to confer protection against infection from encapsulated bacteria in infants between the ages of 3 months and about 2 years.
Claims17
A carrier protein that comprises a P23TT, P32TT, P21TT, PFT3, P30 TT, P2TT, HBVnc, influenza hemagglutinin (HA), HbsAg and influenza matrix (MT) CD4+ T cell epitopes.
Dependencies are inferred from the claim text.