Purified populations of stem cells
AssigneesCornell Research Foundation, Inc., Sloan-Kettering Institute for Cancer Research, ImClone System Incorporated
InventorsShahin Rafii, Larry Witte, Malcolm A. S. Moore
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Abstract
The invention is directed to a purified population of mammalian endothelial, muscle, or neural stem cells. The invention further provides methods for isolating such populations of cells; methods for using such populations of cells for treating mammals; methods for making vectors for gene therapy; and methods for carrying out gene therapy with such vectors.
Claims13
An isolated or purified population of mammalian endothelial stem cells comprising two endothelial stem cell markers on the surface of the endothelial stem cells, wherein one of the endothelial stem cell markers is a vascular endothelial growth factor (VEGF) receptor and the other endothelial stem cell marker is selected from the group consisting of AC133 and CD34, and wherein the purified population of mammalian endothelial stem cells is substantially fine of cells that do not express the two endothelial stem cell markers.
Dependencies are inferred from the claim text.