Radio-opaque polymeric biomaterials
AssigneeRutgers, The State University
InventorsJoachim B. Kohn, Durgadas Bolikal, Sanyog M. Pendharkar
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Abstract
Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.
Claims52
A radio-opacifying diphenol compound substituted with at least one bromine or iodine atom, and having the structure:
- wherein X1 and X2 are independently iodine or bromine, Y1 and Y2 are independently 0, 1 or 2, and R9 is an alkyl, aryl or alkylaryl group containing up to 18 carbon atoms.
A radio-opaque polymeric biomaterial comprising a monomeric repeating units substituted with at least one bromine or iodine atom, and having the structure:
- wherein each X1 and X2 are independently iodine or bromine, each Y1 and Y2 are independently 0, 1 or 2, and R9 is an alkyl, aryl or alkylaryl group containing up to 18 carbon atoms.
A radio-opaque biocompatible polymer comprising monomeric repeating units substituted with at least one bromine or iodine atom, and having the structure:
- wherein each X2 is independently I or Br;
- each Y2 is 1 or 2;
- each R5 and R6 are each independently selected from the group consisting of H, Br, I and straight and branched alkyl groups having up to 18 carbon atoms, each R0 is selected from the group consisting of —CH═CH—, —CHJ1—CHJ2— and (—CH2—)d and each R15 is selected from the group consisting of —CH═CH—, (—CH2—)m and —CHJ1—CHJ2—, wherein each J1 and J2 are independently Br or I;
- and d and m are independently between 0 and 8, inclusive;
- and each Z is independently selected from the group consisting of hydrogen, a free carboxylic acid group or an ester or amide thereof, said ester or amide comprising straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms and esters and amides of biologically and pharmaceutically active compounds.
Dependencies are inferred from the claim text.