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US 6,852,212 B2Granted
Method and apparatus for automatic analysis
AssigneeLifeScan, Inc.
InventorsIan Andrew Maxwell, Thomas William Beck, Alastair McIndoe Hodges
Life of this patent
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Abstract
This invention relates to a method for analyzing the concentration of an analyte in a sample and to automatic analyzing apparatus. The invention will be described herein with particular reference to a method and apparatus for measuring the concentration of glucose or other analytes in blood but is not limited to that use.
Claims18
A method for estimating the concentration of a reduced or oxidized form of a redox species in a liquid comprising the steps of:
- (1) contacting an area of a first electrode with a sample of predetermined volume of the liquid,
- (2) bringing a second electrode into a closely spaced relationship with the first electrode, thereby contacting the sample with an area of the second electrode spaced apart from the first, wherein step (2) is conducted after step (1),
- (3) applying a potential between the electrodes while the electrodes are sufficiently closely spaced that reaction products formed at each electrode diffuse to the other electrode while the potential is applied,
- (4) measuring or estimating a value indicative of the change in current as a function of time and a value indicative of the steady state current, and
- (5) determining from said value, said current as a function of time, and said steady state current the concentration of reduced or oxidized form of the species in the liquid sample wherein at least one of the electrodes is in the form of a continuous strip.
2 more elements
An automatic analyzing apparatus comprising:
- a first electrode,
- means for placing a predetermined volume of a liquid sample in contact with the first electrode,
- means for bringing a second electrode into a closely spaced relationship with the first electrode after a predetermined volume of a liquid sample has been brought in contact with the first electrode, thereby contacting the sample with the second electrode spaced from the first,
- means for applying a potential between the electrodes, and
- means for measuring the current as a function of time while the electrodes are in sufficiently close proximity that reaction products formed at one electrode diffuse to the other and achieve a steady state distribution wherein a volume intermediate the electrode surfaces when the current is measured is not contained by a cell.
2 more elements
An automatic analyzing apparatus comprising:
- a first electrode,
- means for placing a predetermined volume of a liquid sample in contact with the first electrode,
- means for bringing a second electrode into a closely spaced relationship with the first electrode after a predetermined volume of a liquid sample has been brought in contact with the first electrode, thereby contacting the sample with the second electrode spaced from the first,
- means for applying a potential between the electrodes, and
- means for measuring the current as a function of time while the electrodes are in sufficiently close proximity that reaction products formed at one electrode diffuse to the other and achieve a steady state distribution wherein at least one electrode is in the form of a continuous strip.
2 more elements
An automatic analyzing apparatus comprising:
- a first electrode,
- means for placing a predetermined volume of a liquid sample in contact with the first electrode,
- means for bringing a second electrode into a closely spaced relationship with the first electrode after a predetermined volume of a liquid sample has been brought in contact with the first electrode, thereby contacting the sample with the second electrode spaced from the first,
- means for applying a potential between the electrodes, and
- means for measuring the current as a function of time while the electrodes are in sufficiently close proximity that reaction products formed at one electrode diffuse to the other and achieve a steady state distribution wherein at least one electrode is on a flexible backing.
2 more elements
An automatic analyzing apparatus comprising:
- a first electrode,
- means for placing a predetermined volume of a liquid sample in contact with the first electrode,
- means for bringing a second electrode into a closely spaced relationship with the first electrode after a predetermined volume of a liquid sample has been brought in contact with the first electrode, thereby contacting the sample with the second electrode spaced from the first,
- means for applying a potential between the electrodes, and
- means for measuring the current as a function of time while the electrodes are in sufficiently close proximity that reaction products formed at one electrode diffuse to the other and achieve a steady state distribution wherein at least one of the first electrode and the second electrode is mounted on a carousel.
2 more elements
Dependencies are inferred from the claim text.