Positively charged membrane

A device comprising a housing comprising at least one inlet and at least one outlet and defining a fluid flow path between the inlet and the outlet, and, interposed between the inlet and the outlet and across the fluid flow path, at least one positively charged microporous membrane comprising a porous substrate and a crosslinked coating including a polymer backbone and pendant positively charged groups, wherein each pendant positively charged group is directly linked to the backbone through a polar spacer group by a single bond.

A device for tangential flow filtration comprising a housing comprising an inlet and a first outlet and a second outlet;

• the device defining a first fluid flow path between the inlet and the first outlet, and defining a second fluid flow path between the inlet and the second outlet, and, interposed between the inlet and the first outlet and across the first fluid flow path;
• and,
• interposed between the inlet and the first outlet and across the first fluid flow path, and interposed between the inlet and the second outlet and tangential to the second fluid flow path, at least one positively charged microporous membrane comprising a porous substrate and a crosslinked coating including a polymer backbone and pendant positively charged groups, wherein each pendant positively charged group is directly linked to the backbone through a polar spacer group by a single bond.