Monitoring of physiological analytes
AssigneeCygnus, Inc.
InventorsBret Berner, Chia-Ming Chiang, Michael D. Garrison, Janan Jona, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
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Abstract
Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
Claims27
A method for measuring an amount or concentration of an analyte present in a biological system, said method comprising
- contacting one or more samples, comprising said analyte, with a sensing electrode;
- obtaining a measurement signal from each sample comprising analyte using said sensing electrode that is related to analyte amount or concentration in said biological system;
- and
- applying one or more processes for selectively favoring analyte-specific signal components over signal components due to interfering species, said processes selected from the group consisting of (a) selective electrochemical detection process that is performed during said obtaining, said process comprising contacting each sample with an electrochemical sensing electrode that is maintained at a potential less than about 0.6V, (b) a purge step that is performed before and/or after said obtaining, wherein said purge step substantially removes residual signal components from the sensing electrode, and (c) any combinations thereof.
A monitoring system for measuring an analyte present in one or more samples in a biological system, said system comprising:
- a sensing device comprising a sensing electrode, wherein said sensing electrode obtains a measurement signal from the analyte in each of said samples, and said measurement signal is specifically related to the analyte amount or concentration;
- and
- one or more microprocessors in operative communication with the sensing device, wherein said one or more microprocessors comprise programming to control (i) operating said sensing device to provide said measurement signals, and (ii) applying one or more processes for selectively favoring analyte-specific signal components over signal components due to interfering species, said processes selected from the group consisting of (a) selective electrochemical detection process that is performed during said obtaining, said process comprising contacting each of said samples with an electrochemical sensing electrode that is maintained at a potential less than about 0.6V, (b) a purge step that is performed before and/or after said obtaining, wherein said step substantially removes residual signal components from the sensing electrode, and (c) any combinations thereof.
Dependencies are inferred from the claim text.