Lipid hydrolysis therapy for atherosclerosis and related diseases
AssigneeChildren's Hospital Research Foundation
InventorsGregory Grabowski, Hong Du
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Abstract
The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances which are capable of lipid removal, primarily through hydrolysis, either by a catalytic or stoichiometric process, wherein the substance targets receptors in and/or on the cell which lead to uptake into the lysosome. Such substances used to diminish and/or eliminate atherosclerotic plaques are generally comprised of lipid hydrolyzing proteins and/or polypeptides.
Claims29
A process for reducing atherosclerotic plaques in a mammal comprising administering to said mammal a safe and effective amount of lysosomal acid lipase, sufficient to effect a reduction in the amount of atherosclerotic plaques in said mammal.
A method for treatment of atherosclerosis in a mammal comprising administering to said mammal a safe and effective amount of a lysosomal acid lipase, sufficient to treat said condition.
A method for treatment of atherosclerosis in a mammal comprising administering to said mammal a safe and effective amount of exogenously produced lysosomal acid lipase sufficient to treat said condition.
Dependencies are inferred from the claim text.