System and method for the production of 18F-Fluoride
AssigneeTriumf
InventorsThomas J. Ruth, Kenneth R. Buckley, Kwonsoo Chun, Salma Jivan, Stefan K. Zeisler
Life of this patent
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Abstract
A system and method for producing 18F-Fluoride by using a proton beam to irradiate 18Oxygen in gaseous form. The irradiated 18Oxygen is contained in a chamber that includes at least one component to which the produced 18F-Fluoride adheres. A solvent dissolves the produced 18F-Fluoride off of the at least one component while it is in the chamber. The solvent is then processed to obtain the 18F-Fluoride.
Claims19
A method for preparing 18F-Fluoride from 18Oxygen, the method comprising the steps:
- obtaining molecules of 18Oxygen in gaseous form in a chamber that includes at least one component to which 18F-Fluoride adheres;
- irradiating the 18Oxygen gas in the chamber by a proton beam through a chamber window, a portion of the proton beam passing through the chamber window and reaching the 18Oxygen gas within the chamber having a beam current of 100 μA or more and converting a portion of the 18Oxygen into 18F-Fluoride, the converted 18F-Fluoride adhering to the at least one component;
- and
- exposing the at least one component to a solvent within the chamber, the solvent dissolving the 18F-Fluoride adhered to the at least one component while substantially maintaining a constant orientation between the chamber window and the at least one component during the irradiating and exposing steps.
A method for preparing 18F-Fluoride from 18Oxygen the method comprising the steps:
- placing molecules of 18Oxygen in gaseous form in a chamber that includes at least one component having a surface of nickel, stainless steel, or glassy carbon, to which 18F-Fluoride adheres;
- irradiating the 18Oxygen gas in the chamber by passing a proton beam through a chamber window, thus converting a portion of the 18Oxygen into 18F-Fluoride, wherein the converted 18F-Fluoride preferentially adheres to the at least one component;
- and
- exposing the at least one component to a solvent within the chamber while substantially maintaining a constant orientation between the chamber window and the at least one component during the irradiating and exposing steps, the solvent dissolving the 18F-Fluoride adhered to the at least one component.
A method for preparing 18F-Fluoride from 18Oxygen the method comprising the steps:
- obtaining molecules of 18Oxygen in gaseous form in a chamber that includes at least one component to which 18F-Fluoride adheres;
- irradiating the 18Oxygen gas in the chamber by passing a proton beam through a chamber window, a portion of the proton beam reaching the 18Oxygen gas having a beam energy of at least 17.5 MeV, thus converting a portion of the 18Oxygen into 18F-Fluoride, the converted 18F-Fluoride adhering to the at least one component;
- and
- exposing the at least one component to a solvent within the chamber while substantially maintaining a constant orientation between the chamber window and the at least one component during the irradiating and exposing steps, the solvent dissolving the 18F-Fluoride adhered to the at least one component.
A method for preparing 18F-Fluoride from 18Oxygen, the method comprising the steps:
- obtaining molecules of 18Oxygen in gaseous form in a chamber that includes at least one component to which 18F-Fluoride adheres;
- irradiating the 18Oxygen gas in the chamber by passing a proton beam through a chamber window, a portion of the proton beam reaching the 18Oxygen gas having a beam power of at least 1.0 kilowatt, thus converting a portion of the 18Oxygen into 18F-Fluoride, the converted 18F-Fluoride adhering to the at least one component;
- and
- exposing the at least one component to a solvent within the chamber while substantially maintaining a constant orientation between the chamber window and the at least one component during the irradiating and exposing steps, the solvent dissolving the 18F-Fluoride adhered to the at least one component.
Dependencies are inferred from the claim text.