Methods for inhibiting rejection of transplanted tissue
AssigneeThe General Hospital Corporation
InventorDenise Faustman
Life of this patent
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Abstract
A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in said animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of said animal without causing lysis of said cell.
Claims7
A transplantable composition for use in humans comprising isolated cells or isloated tissue of a type normally bearing an HLA class I surface antigen that causes an immune response against the cell or tissue in a human recipient, wherein the antigen is masked to decrease said immune response, such that upon introduction of the composition into a human, lysis of said cell or tissue is prevented;
- wherein
- said class I antigen is masked by contacting said cell or tissue with an antibody lacking the Fc portion, which does not fix complement and, which is capable of forming a complex with said class I antigen on said cell or tissue.
Dependencies are inferred from the claim text.