Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
AssigneeGambro AB
InventorsDennis J. Hlavinka, Raymond P. Goodrich, Laura Goodrich, Daniel McGraw
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Abstract
Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, nontoxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
Claims38
A method for inactivating pathogens in a fluid containing red blood cells comprising;
- adding a photosensitizcr to the fluid to form a mixture, and
- exposing the mixture of the fluid and the photosensitizer to light having a peak wavelength of approximately 470 nm.
A method for inactivating pathogens in a fluid containing platelets comprising;
- adding a photosensitizer to the fluid to form a mixture, and
- exposing the mixture of the fluid and the photosensitizer to light within an approximate range of between 305-313 nm.
A treatment chamber for inactivating pathogens in a fluid containing red blood cells and a photosensitizer comprising:
- at least one radiation emitting source emitting radiation at a peak wavelength of approximately 470 nm;
- a support platform for holding the fluid containing red blood cells and photosensitizer to be irradiated;
- and
- a control unit for controlling the radiation emitting source.
A treatment chamber for inactivating pathogens in a fluid containing platelets and a photosensitizer comprising:
- at least one radiation emitting source emitting radiation at a peak wavelength of approximately 308 nm;
- a support platform for holding the fluid containing platelets and photosensitizer to be irradiated;
- and
- a control unit for controlling the radiation emitting source.
A method of irradiating a fluid containing platelets comprising the steps of:
- adding an amount of photosensitizer to the fluid necessary to inactivate any pathogens contained in the fluid;
- exposing the fluid and photosensitizer to light at a wavelength of approximately 308 nm;
- end
- mixing the fluid and photosensitizer during the exposing step to expose the majority of the fluid to the light.
A method of irradiating rod blood cells in a fluid contained within a photopermeable bag comprising the steps of:
- adding riboflavin to the bag in an amount necessary to inactivate any pathogens contained in the fluid:
- exposing the bag containing at least the fluid and riboflavin to a peak wavelength of light;
- and
- mixing the contents of the bag during the exposing step.
A method of irradiating a blood product comprising the steps of:
- a) adding an amount of photosensitizer necessary to inactivate any pathogens contained in the blood product:
- b) pulsing a radiation source having a peak wavelength of light of approximately 470 nm to expose the blood product and photosensitizer to radiation at the peak wavelength;
- c) pulsing the radiation source off to stop exposure of the blood product and photosensitizer to radiation;
- d) mixing the blood product and photosensitizer during the step of pulsing the radiation source off;
- and
- e) repeating steps b), c) and d).
Dependencies are inferred from the claim text.