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US 6,841,684 B2Granted
Imidiazoles having reduced side effects
AssigneeAllergan, Inc.
InventorsKen Chow, Daniel W. Gil, James A. Burke, Dale A. Harcourt, Michael E. Garst, Larry A. Wheeler, Stephen A. Munk, Dario G. Gomez, Todd M. Heidelbaugh
Life of this patent
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Abstract
Methods and compounds for the treatment of conditions including pain, particularly chronic pain, glaucoma or elevated intraocular pressure with reduced cardiovascular or sedative side effects. Also included are methods of making and using such compounds.
Claims18
A compound selected from the group consisting of:
- wherein R1 is independently selected from the group consisting of H;
- halogen;
- C1-4 alkyl;
- C1-4 alkenyl;
- C1-4 alkynyl;
- —COR4 where R4 is H, C1-4 alkyl or C1-4 alkoxy;
- C3-6 cycloalkyl;
- aryl;
- cyano;
- nitro;
- trihalomethyl;
- oxo;
- or —(CH2)n —X—(CH2)m—(R5)o— where X is O, S or N, n is 0-3, m is 0-3, o is 0-1, and R5 is methyl or H1-2, each R6 is independent selected from the group consisting of H;
- halogen;
- C1-4 alkyl;
- C1-4 alkenyl;
- C1-4 alkynyl;
- —COR4 where R4 is H, C1-4 alkyl or C1-4 alkoxy;
- C3-6 cycloalkyl;
- aryl;
- cyano;
- nitro;
- trihalomethyl and oxo wherein each p is independently 1 or 2 and Y is —(C(R7)z)2—, wherein R7 is independently defined identically to R1 and z is independently 1 or 2, said compound further having selective agonist activity at the α2B or α2B/α2C adrenergic receptor subtype(s) over the α2A adrenergic receptor subtype, and all pharmacologically acceptable salts, esters, stereoisomers and racemic mixtures thereof.
20 more elements
Dependencies are inferred from the claim text.