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US 6,838,528 B2Granted
Multi-arm block copolymers as drug delivery vehicles
AssigneeNektar Therapeutics AL, Corporation
InventorXuan Zhao
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AssigneeNektar Therapeutics AL, Corporation
InventorXuan Zhao
Estimating the term…
The invention provides multi-arm block copolymers useful as drug delivery vehicles comprising a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, methods of making such copolymers and pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
A multi-arm block copolymer useful as a drug delivery vehicle, comprising a central core molecule comprising a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region, and wherein the hydrophobic polymer segment comprises a poly(hydroxyester).
A multi-arm block copolymer useful as a drug delivery vehicle, comprising a central core molecule comprising a residue of a polyol having at least 3 hydroxyl groups, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region, and wherein the hydrophobic polymer segment is a poly(hydroxyester) and the hydrophilic polymer segment is poly(ethylene glycol).
A multi-arm block copolymer useful as a drug delivery vehicle, comprising a central core molecule comprising a residue of a polyol having 3 to about 8 hydroxyl groups, and 3 to about 8 copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region, and wherein the hydrophobic polymer segment is a poly(hydroxyester) having a number average molecular weight of about 500 Da to about 40,000 Da and the hydrophilic polymer segment is a linear or branched poly(ethylene glycol) having a number average molecular weight of about 500 Da to about 100,000 Da.
Dependencies are inferred from the claim text.