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US 6,838,073 B1Granted
Cobalamin conjugates useful as imaging and therapeutic agents
AssigneesMayo Foundation for Medical Education and Research, Regents of the University of Minnesota
InventorsDouglas A. Collins, Henricus P. C. Hogenkamp
Life of this patent
Estimating the term…
Abstract
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
Claims41
A compound wherein a residue of a compound of formula I
- is linked to one or more peptide residues or amino acid residues wherein X is CN, OH, CH3 or adenosyl, and at least one of the peptide residues or the amino acid residues is linked to one or more chelating groups comprising one or more metallic radionuclides;
- or a pharmaceutical acceptable salt thereof.
A compound wherein a residue of a compound of formula I
- is linked to one or more residues of the formula —[NHCH[(CH2)4NH2—DET]CO—]n—Q wherein Q is H, (C1-C14)alkyl, or a suitable carboxy protecting group;
- X is CN, OH, CH3 or adenosyl;
- DET is a chelating group residue comprising a metallic radionuclide;
- and n is between 2 and about 20;
- or a pharmaceutically acceptable salt thereof.
2 more elements
A compound wherein a residue of a compound of formula I
- is linked to a residue of a peptide which is linked to one or more chelating groups comprising a metallic radionuclide;
- and X is CN, OH, CH3 or adenosyl;
- or a pharmaceutically acceptable salt thereof.
A compound wherein a residue of a compound of formula I
- is linked to a residue of an amino acid which is linked to one or more chelating groups comprising a metallic radionuclide;
- and X is CN, OH, CH3 or adenosyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.