Bioprocess container, bioprocess container mixing device and method of use thereof

A method for mixing comprising:

• providing a bioprocess container (BPC), said BPC comprising:
• a flexible container having a size and shape when at least partially filled, and
• a rigid heat exchanger, having liquid-transfer media and a heat exchanging cavity, said container disposed at least partially inside said cavity and in contact with said heat exchanger, said cavity having a portion corresponding essentially to the shape of said container and
• at least one manipulating element selected from the group consisting of:
• at least one bladder integral with or adjacent to the structure of said container and at least one inflating apparatus, in fluid communication with said at least one bladder;
• and
• a plurality of fluid-containing sleeves protruding from the interior of said container and a means for squeezing said plurality of fluid-containing sleeves;
• and
• agitating the contents of the container.