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US 6,833,536 B2Granted
Non-contact radiant heating and temperature sensing device for a chemical reaction chamber
AssigneeApplera Corporation
InventorJohn Shigeura
Life of this patent
Estimating the term…
Abstract
An apparatus and methods are provided for heating and sensing the temperature of a chemical reaction chamber without direct physical contact between a heating device and the reaction chamber, or between a temperature sensor and the reaction chamber. A plurality of chemical reaction chambers can simultaneously or sequentially be heated independently and monitored separately.
Claims30
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber, the heatable device being spaced from the non-contact radiant heater a distance of from about five mm to about 20 mm, being spaced from the non-contact radiant temperature sensor a distance of from about five to about 20 mm, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor.
1 more element
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber having at least one sample-confining dimension of about 600 μm or less, the heatable device being spaced from the non-contact radiant heater, spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor.
1 more element
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber including a sidewall having an outer surface of a first area, the heatable device being spaced from the non-contact radiant heater, spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor, wherein the non-contact radiant temperature sensor has a field of view that intersects the outer surface of the sidewall at a second area that is smaller than the first area.
1 more element
A method of heating a biochemical sample comprising:
- providing a heatable device that includes a reaction chamber retaining a sample, the reaction chamber having at least one sample-confining dimension of about 600 μm or less;
- heating the reaction chamber with a non-contact radiant heater spaced from the heatable device;
- and
- sensing a temperature of the reaction chamber with a non-contact temperature sensor spaced from the heatable device.
1 more element
A method of heating a biochemical sample comprising:
- providing a heatable device that includes a reaction chamber retaining a sample;
- heating the reaction chamber with a non-contact radiant heater spaced from the heatable device a distance of from about five mm to about 20 mm;
- and
- sensing a temperature of the reaction chamber with a non-contact temperature sensor spaced from the heatable device a distance of from about five mm to about 20 mm.
1 more element
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor;
- and
- a first platform region supporting the non-contact radiant heater, and a second platform region supporting the non-contact radiant temperature sensor, wherein a plurality of non-contact radiant heaters are supported by the first platform region, and a plurality of non-contact radiant temperature sensors are supported by the second platform region.
2 more elements
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor,
- wherein the heatable device is spaced away from the non-contact radiant heater by a distance of from about five mm to about 20 mm.
2 more elements
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor,
- wherein the non-contact radiant heater comprises a laser source.
2 more elements
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor,
- wherein the non-contact radiant heater comprises a halogen light source.
2 more elements
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor;
- and
- a biochemical sample including a nucleic acid sequence in the reaction chamber and sufficient components to enable at least one cycle of polymerase chain reaction of the nucleic acid sequence.
2 more elements
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor,
- wherein the heatable device is spaced away from the non-contact radiant temperature sensor by a distance of from about five mm to about 20 mm.
2 more elements
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor,
- wherein the heatable device is a microfluidic analytical device.
2 more elements
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor,
- wherein the reaction chamber has at least one dimension that is less than or equal to 500 μm.
2 more elements
A heating system comprising:
- a non-contact radiant heater;
- a non-contact radiant temperature sensor;
- and
- a heatable device including a chemical reaction chamber having a volume of about 10 ml or less, the heatable device being spaced from the non-contact radiant heater spaced from the non-contact radiant temperature sensor, and positioned for the chemical reaction chamber to receive heat irradiated by the non-contact radiant heater and for the chemical reaction chamber to radiate heat toward the non-contact radiant temperature sensor,
- wherein the non-contact radiant temperature sensor has a field of view that falls within a surface of the reaction chamber.
2 more elements
A method of heating a biochemical sample comprising:
- providing a heatable device that comprises a plurality of reaction chambers retaining a sample, the reaction chambers each having a volume of about 10 ml or less, a plurality of non-contact radiant heaters are provided, and a plurality of non-contact radiant temperature sensors are provided;
- heating the plurality of reaction chambers with a plurality of non-contact radiant heaters spaced from the heatable device;
- and
- sensing temperatures of the plurality of reaction chambers with a plurality of non-contact temperature sensor spaced from the heatable device.
1 more element
A method of heating a biochemical sample comprising:
- providing a heatable device that includes a reaction chamber retaining a sample, the reaction chamber having a volume of about 10 ml or less;
- heating the reaction chamber with a non-contact radiant heater spaced from the heatable device;
- and
- sensing a temperature of the reaction chamber with a non-contact temperature sensor spaced from the heatable device,
- wherein the heating comprises heating with laser-produced radiation.
2 more elements
A method of heating a biochemical sample comprising:
- providing a heatable device that includes a reaction chamber retaining a sample, the reaction chamber having a volume of about 10 ml or less;
- heating the reaction chamber with a non-contact radiant heater spaced from the heatable device;
- and
- sensing a temperature of the reaction chamber with a non-contact temperature sensor spaced from the heatable device,
- wherein the heating comprises heating with a halogen light source.
2 more elements
A method of heating a biochemical sample comprising:
- providing a heatable device that includes a reaction chamber retaining a sample, the reaction chamber having a volume of about 10 ml or less;
- heating the reaction chamber with a non-contact radiant heater spaced from the heatable device;
- and
- sensing a temperature of the reaction chamber with a non-contact temperature sensor spaced from the heatable device,
- wherein the non-contact radiant heater produces radiation having a wavelength of about 0.7 micrometer or longer.
2 more elements
A method of heating a biochemical sample comprising:
- providing a heatable device that includes a reaction chamber retaining a sample, the reaction chamber having a volume of about 10 ml or less, wherein the sample comprises a nucleic acid sequence and sufficient components to enable at least one cycle of polymerase chain reaction of the nucleic acid sequence;
- heating the reaction chamber with a non-contact radiant heater spaced from the heatable device;
- sensing a temperature of the reaction chamber with a non-contact temperature sensor spaced from the heatable device;
- and
- cycling the temperature of the reaction chamber in a manner sufficient to effect polymerase chain reaction of the nucleic acid sequence.
2 more elements
Dependencies are inferred from the claim text.