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US 6,833,361 B2Granted
Nucleosides having bicyclic sugar moiety
AssigneeRibapharm, Inc.
InventorsZhi Hong, Haoyun An
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Abstract
Conformationally restricted 2′, 4′-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2′ and C4′ of nucleosides through a linker or linking molecule. These novel nucleosides have a desired, locked sugar pucker and are potentially useful as pharmaceutical ingredients, and especially for use in treatment of HCV.
Claims11
A compound having the following formula:
- wherein X is O:
- Y is O and Z is CH2;
- R1 is a heterocyclic base;
- and
- R2 and R3 are independently H, OH, halogen, protected hydroxyl, CN, N3, OCH3, or W, wherein W is monosphosphate, diphosphate, triphosphate, monophosphate, diphosphonate, triphosphonate, an amino acid ester with an OH group the sugar portion, or a prodrug of the monophosphate, diphosphate, triphosphate, monophosphonate, diphosphonate, or triphosphonate.
2 more elements
Dependencies are inferred from the claim text.