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US 6,833,252 B1Granted
Nucleotide sequence encoding the enzyme I-SecI and the uses thereof
AssigneesInstitut Pasteur, Universite Pierre et Marie Curie
InventorsBernard Dujon, Andre Choulika, Arnaud Perrin, Jean-Francois Nicolas
Life of this patent
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Abstract
An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.
Claims19
A recombinant mammalian chromosome comprising an exogenous Group I intron encoded endonuclease site,
- wherein the endonuclease site is within an integrated nucleic acid sequence from a vector,
- wherein the site is selected from the group consisting of an I-SceIV site, an I-CsmI site, I-PanI site, I-SceII site, an I-CeuI site, an I-PpoI site, an I-SceIII site, an I-CreI site, an I-TevI site, an I-TevII site, an I-TevIII site, and an I-SceI site.
Dependencies are inferred from the claim text.