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US 6,831,086 B1Granted
Process for the inactivation of viruses with the aid of acridine derivatives
AssigneeZLB Behring GmbH
InventorDieter Bernhardt
Life of this patent
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Abstract
The invention relates to the use of acridine or acridine derivatives, preferably in combination with benzalkonium chloride, for the inactivation of enveloped or nonenveloped viruses. The process according to the invention is preferably carried out in the presence of proteins whose biological activity is substantially retained.
Claims23
A process for inactivating viruses, comprising:
- (a) forming a composition by adding acridine or an acridine derivative to a material suspected to contain viruses, wherein the acridine or acridine derivative is present at non-cytotoxic concentrations;
- and
- (b) incubating the composition of step (a) in vitro;
- wherein the acridine derivative is selected from the group consisting of ethacridine, 9-aminoacridine, 3,6 acridinediamine, acrisorcin acrizane, acridine orange, quinacrine, acricide, acridone, acridine-9-carboxylic acid, acranil, phenosafranin, phenoxazine, phenothiazine, acriflavine, and salts thereof.
1 more element
A process for inactivating viruses, comprising:
- (a) forming a composition by adding benzalkonium chloride and acridine or an acridine derivative to a material suspected to contain viruses, wherein the benzalkonium chloride is present at a concentration up to 0.1 g/l and the acridine or acridine derivative is present at non-cytotoxic concentrations;
- and
- (b) incubating the composition of step (a) in vitro,
- wherein the material further comprises at least one protein that retains its biological activity.
1 more element
Dependencies are inferred from the claim text.