Hydroxy and amine functionalized resins
AssigneeCarlsberg A/S
InventorsMorten Peter Meldal, Thomas Groth
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Abstract
A star-blocked polymeric material based on polyethylene glycol and having a uniform distribution of both hydroxy and amine functional groups throughout the polymeric material is described. The polymeric material, known as HYDRA (hydroxy and amine functionalized resin), is prepared by forming a polyimine compound by reacting an aldehyde and an amine. The polyimine is then reacted with a reducing agent to form a star-blocked polymeric material. HYDRA resins can be used, for example, as solid supports for organic synthesis, for enzymatic assays, for immobilization of biomolecules, for controlled release of drugs, and for chromatographic separations.
Claims51
A polymeric material comprising the reaction product of:
- (a) a polyimine formed by reacting an aldehyde and an amine;
- and
- (b) a reducing agent,
- wherein the polymeric material is a star-block polymer having both amine and hydroxy functionality.
A polymeric material comprising polyethylene glycol chains cross-linked with a branching compound to form a star-block polymer having both amine and hydroxy functional groups, wherein the polyethylene glycol chains contain 2 to about 1,000 ethylene glycol units.
A method of preparing a polymeric material comprising:
- (a) reacting an amine and an aldehyde to form a polyimine;
- (b) reducing the polyimine with a reducing agent to form a star-block polymer having amine and hydroxy functionality.
Dependencies are inferred from the claim text.