Compound comprising crosslinked polyrotaxane
AssigneeCenter for Advanced Science and Technology Incubation, Ltd.
InventorsYasushi Okumura, Kohzo Ito
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Abstract
A novel compound and novel gelatinous substance which have high absorbability, uniform expansion, and elasticity. Although conventional gels include chemical gels and physical gels, no novel gels or compounds have been realized which have fracture resistance, high entropic elasticity, and biodegradability. The present invention provides a novel compound and a novel gelatinous substance which each comprises a crosslinked polyrotaxane obtained by chemically bonding two or more polyrotaxane molecules through the cyclic molecules or rotators thereof.
Claims73
A compound comprising crosslinked polyrotaxane, wherein the crosslinked polyrotaxane has a first and a second polyrotaxane, the first polyrotaxane having a first linear molecule and a first cyclic molecule, the first linear molecule having the first cyclic molecule included in a skewered manner which allows the first linear molecule to pass through the opening of the first cyclic molecule, and having at each end a first blocking group which is placed so as to prevent the elimination of the first cyclic molecule, the second polyrotaxane having a second linear molecule and a second cyclic molecule, the second linear molecule having the second cyclic molecule included in a skewered manner which allows the second linear molecule to pass through the opening of the second cyclic molecule, and having at each end a second blocking group which is placed so as to prevent the elimination of the second cyclic molecules, each opening of the first and second cyclic molecules is substantially cylic, and the crosslinked polyrotaxane is formed by linking at least one of the first cyclic molecules and at least one of the second cyclic molecules via chemical bonding.
A compound comprising crosslinked polyrotaxane, wherein the crosslinked polyrotaxane has a first and a second polyrotaxane, the first polyrotaxane having a first linear molecule and a first cyclic molecule, the first linear molecule having the first cyclic molecule included in a skewered manner which allows the first linear molecule to pass through the opening of the first cyclic molecule, and having at each end a first blocking group which is bulky enough to prevent the elimination of the first cyclic molecule, the second polyrotaxane having a second linear molecule and a second cyclic molecule, the second linear molecule having the second cyclic molecule included in a skewered manner which allows the second linear molecule to pass through the opening of the second cyclic molecule, and having at each end a second blocking group which is bulky enough to prevent the elimination of the second cyclic molecules, and the crosslinked polyrotaxane is formed by linking at least one of the first cyclic molecules and at least one of the second cyclic molecules via chemical bonding.
Crosslinked polyrotaxane comprising at least two polyrotaxane molecules, each of which has a polyethylene glycol molecule and an alpha-cyclodextrin molecule, the polyethylene glycol molecule having the alpha-cyclodextrin molecule included in a skewered manner which allows the polyethylene glycol molecule to pass through the opening of the alpha-cyclodextrin molecule, and having at each end a blocking group which is placed so as to prevent the elimination of the alpha-cyclodextrin molecule, wherein the crosslinked polyrotaxane is formed by linking the alpha-cyclodextrin molecule of each of the two polyrotaxane molecules to each other via chemical bonding.
Crosslinked polyrotaxane comprising at least two polyrotaxane molecules, each of which has a polyethylene glycol molecule and an alpha-cyclodextrin molecule, the polyethylene glycol molecule having the alpha-cyclodextrin molecule included in a skewered manner which allows the polyethylene glycol molecule to pass through the opening of the alpha-cyclodextrin molecule, and having at each end a blocking group which is bulky enough to prevent the elimination of the alpha-cyclodextrin molecule, wherein the crosslinked polyrotaxane is formed by linking the alpha-cyclodextrin molecules of each of the two polyrotaxane molecules to each other via chemical bonding.
A process for producing a compound comprising crosslinked polyrotaxane, comprising the steps of:
- mixing a cyclic molecule and a linear molecule to prepare polyrotaxane in which the linear molecule has the cyclic molecule included in a skewered manner which allows the linear molecule to pass through the opening of the cyclic molecules, blocking each end of the linear molecule with a blocking group so as to prevent the elimination of the cyclic molecule from the skewered state, and crosslinking two or more polyrotaxanes by linking the cyclic molecules to each other via chemical bonding, and wherein each opening of the cyclic molecules is substantially cyclic.
A process for producing a compound comprising crosslinked polyrotaxane, comprising the steps of:
- mixing a cyclic molecule and a linear molecule to prepare polyrotaxane in which the linear molecule has the cyclic molecule included in a skewered manner which allows the linear molecule to pass through the opening of the cyclic molecule, blocking each end of the linear molecule with a blocking group so as to prevent the elimination of the cyclic molecules from the skewered state, and crosslinking two or more polyrotaxanes by linking the cyclic molecules to each other via chemical bonding.
A process for producing a compound comprising crosslinked polyrotaxane, comprising the steps of:
- mixing alpha-cyclodextrin and polyethylene glycol to prepare polyrotaxane in which the polyethylene glycol has the alpha-cyclodextrin included in a skewered manner which allows the polyethylene glycol to pass through the opening of the alpha-cyclodextrin, blocking each end of the polyethylene glycol molecule with a blocking group so as to prevent the elimination of the alpha-cyclodextrins from the skewered state, and crosslinking two or more polyrotaxane molecules by linking the alpha-cyclodextrins to each other via chemical bonding.
A process for producing a compound comprising crosslinked polyrotaxane, comprising the steps of:
- providing a bicyclic molecule with a first and second substantial rings, mixing the bicyclic molecule with a first linear molecule and a second linear molecule to prepare crosslinked polyrotaxane in which the first linear molecule has the bicyclic molecule included in a skewered manner which allows the first linear molecule to pass through the opening of the first ring of the bicyclic molecule, and the second linear molecule has the bicyclic molecule included in a skewered manner which allows the second linear molecule to pass through the opening of the second ring of the bicyclic molecule, and which is formed by linking the bicyclic molecules;
- and blocking each end of the linear molecules with a blocking group so as to prevent the elimination of the bicyclic molecules from the skewered state.
A compound comprising crosslinked polyrotaxane formed by crosslinking a first polyrotaxane and a second polyrotaxane, wherein the first polyrotaxane has a first linear molecule and a first cyclic molecule, the first linear molecule having the first cyclic molecule included in a skewered manner which allows the first linear molecule to pass through the opening of the first cyclic molecule, and having at each end a first blocking group which is placed so as to prevent the elimination of the first cyclic molecule, the second polyrotaxane has a second linear molecule and a second cyclic molecule, the second linear molecule having the second cyclic molecule included in a skewered manner which allows the second linear molecule to pass through the opening of the second cyclic molecule, and having at each end a second blocking group which is placed so as to prevent the elimination of the second cyclic molecule, each ring of the first and second cyclic molecules is substantially cyclic, and the crosslinking is formed via chemical bonding between at least one of the first cyclic molecules and at least one of the second cyclic molecules, and wherein the first cyclic molecule is movable between the ends of the first linear molecule, and the second cyclic molecule is movable between the ends of the second linear molecule, so that when force is applied to the compound, the first and second cyclic molecules are moved, so as for the force to be equally dispersed, whereby providing the compound having viscoelastic property.
A compound comprising crosslinked polyrotaxane formed by crosslinking a first polyrotaxane and a second polyrotaxane, wherein the first polyrotaxane has a first linear molecule and a first cyclic molecule, the first linear molecule having the first cyclic molecule included in a skewered manner which allows the first linear molecule to pass through the opening of the first cyclic molecule, and having at each end a first blocking group which is placed so as to prevent the elimination of the first cyclic molecule, the second polyrotaxane has a second linear molecule and a second cyclic molecule, the second linear molecule having the second cyclic molecule included in a skewered manner which allows the second linear molecule to pass through the opening of the second cyclic molecule, and having at each end a second blocking group which is placed so as to prevent the elimination of the second cyclic molecule, each ring of the first and second cyclic molecules is, and the crosslinking is formed via chemical bonding between at least one of the first cyclic molecules and at least one of the second cyclic molecules, and wherein the viscoelastic property of the compound is controlled by controlling any one selected from the group consisting of:
- an amount of the first cyclic molecule to be included through the first linear molecule;
- an amount of the second cyclic molecule to be included through the second linear molecule;
- molecular weight and rigidity of the first and second linear molecules;
- and degrees of crosslinking between the first cyclic molecule and the second cyclic molecule.
Dependencies are inferred from the claim text.