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US 6,828,110 B2Granted
Assays for detection of Bacillus anthracis
AssigneeBiosite, Inc.
InventorsBruce A. Lee, Becky Mar Flores, Gunars E. Valkirs
Life of this patent
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Abstract
This invention provides novel methods, reagents, and kits that are useful for detecting B. anthracis. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, which bind to the surface array protein of B. anthracis.
Claims28
A method of specifically detecting the Bacillus anthracis surface array protein SEQ ID NO:1 in a test sample, the method comprising:
- contacting a test sample with a first antibody that specifically binds to Bacillus anthracis surface array protein as set forth in SEQ ID NO:1, wherein the first antibody forms a complex with the surface array protein but does not form a complex with protein from non-anthracis Bacillus species present in the test sample;
- and
- detecting the complex with a labeled second antibody that binds to the complex, wherein the detection of the complex is indicative of the presence of Bacillus anthracis in the test sample.
A kit for detecting the presence or absence of Bacillus anthracis in a sample, the kit comprising:
- a first antibody that specifically binds to the surface array protein set forth in SEQ ID NO:1 but does not bind to protein from non-anthracis Bacillus species;
- and
- a label.
Dependencies are inferred from the claim text.