Dermatological composition containing urea
AssigneeBradley Pharmaceuticals, Inc.
InventorsBradley P. Glassman, Dileep Bhagwat, Daniel Glassman
Life of this patent
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Abstract
Described are dermatological compositions for treating, protecting and re-epitheliazing cutaneous wounds and damaged skin, such compositions including about 21 to about 40% urea and trace amounts of zinc, copper and manganese in the form of their respective pharmaceutically acceptable salts.
Claims26
A dermatological composition comprising from about 21 to about 40 wt-% urea, and trace amounts of zinc, copper and manganese and the balance being dermatologically acceptable excipients.
A dermatological composition comprising:
- (a) about 21 to about 40 wt-% urea;
- (b) trace amounts of zinc, copper and manganese as their pharmaceutically acceptable salts;
- (c) about 5.5 to about 20 wt-% petrolatum or a synthetic or semi-synthetic hydrocarbon, or a semi-solid mixture thereof;
- (d) about 10 to about 20 wt-% of a liquid petrolatum or a synthetic or semi-synthetic oleaginous liquid fraction, or a mixture thereof;
- (e) about 0.25 to about 2 wt-% of a C16-18 aliphatic straight or branched chain fatty alcohol or fatty acid, or a mixture thereof;
- (f) about 1 to about 5 wt-% propylene glycol;
- (g) about 1 to about 3 wt-% glyceryl stearate;
- (h) about 0.01 to about 0.5 wt-% xanthan gum;
- and
- (i) the balance being water.
A dermatological composition consisting essentially of:
- (a) about 21 to about 40 wt-% urea;
- (b) about 1 ppm to about 0.5 wt-% of zinc, copper and manganese as their pharmaceutically acceptable salts;
- (c) about 5.5 to about 20 wt-% petrolatum or a synthetic or semi-synthetic hydrocarbon, or a semi-solid mixture thereof;
- (d) about 10 to about 20 wt-% of a liquid petrolatum or a synthetic or semi-synthetic oleaginous liquid fraction, or a mixture thereof;
- (e) about 0.25 to about 2 wt-% of a C16-18 aliphatic straight or branched chain fatty alcohol or fatty acid, or a mixture thereof;
- (f) about 1 to about 5 wt-% propylene glycol;
- (g) about 1 to about 3 wt-% glyceryl stearate;
- (h) about 0.01 to about 0.5 wt-% xanthan gum;
- (i) about 0.05 to about 30 wt-% of a mixture of a carbomer and thiethanolamine;
- and
- (j) the balance being water.
A method of treating skin disorders and cutaneous wounds comprising applying to an affected area an effective amount of a semi-solid dermatological composition comprising about 21 to about 40 wt-% urea, and trace amounts of zinc, copper and manganese present as their pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.