Polymer composite compositions
AssigneeShriners Hospitals for Children
InventorsThomas J. Koob, Daniel J. Hernandez
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Abstract
The invention relates to methods of treating mixtures containing polymeric materials, e.g., collagen, to form a polymer that intercalates into the polymeric material. The treatment provides greater tensile strength to the mixture, among other advantages. The polymer is formed of a monomeric unit having at least one catechol group that is oxidized to a quinone upon polymerization.
Claims49
A composition comprising a polymeric material, a polymer that intercalates into the polymeric material, and at least one component selected from the group consisting of a cell, a cytokine and a therapeutic agent;
- the polymer comprising monomers, each monomer comprising a first quinone group, a second quinone group, and a linker of at least three carbon atoms between the first quinone group and the second quinone group, wherein no more than one peptide bond separates the first quinone group from the second quinone group.
A composition comprising a polymeric material, a polymer that intercalates into the polymeric material, and at least one component selected from the group consisting of a cell, a cytokine, and a therapeutic agent;
- the polymer comprising monomers, each monomer comprising a first quinone group, and a second reacted group, provided that the reacted group is not an amino or carbonyl group participating in a peptide bond within the monomer.
A method of making a composition, the method comprising:
- combining a polymeric material and a polymer that intercalates into the polymeric material, the polymer comprising monomers, each monomer comprising a catechol group, a reactive group, and a linker of at least three carbon atoms between the catechol group and the reactive group;
- and
- adding to the polymeric material and polymer at least one component selected from the group consisting of a cell, a cytokine, and a therapeutic agent.
A composition comprising:
- (a) a polymeric material;
- (b) a polymer made from one or more catechol-containing monomers;
- and (c) at least one component selected from the group consisting of a cell, a cytokine, and a therapeutic agent.
A composition comprising:
- (a) a collagen fiber comprising intercalated therein a catechol-containing monomer;
- (b) a collagen foam comprising a catechol-containing monomer;
- and (c) at least one component selected from the group consisting of a cell, cytokine, and a therapeutic agent.
Dependencies are inferred from the claim text.