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US 6,818,619 B2Granted
Chimeric natriuretic peptides
AssigneeMayo Foundation for Medical Education and Research
InventorsJohn C. Burnett, Jr., Ondrej Lisy
Life of this patent
Estimating the term…
Abstract
Peptides of Dendroaspis, including chimeric peptides thereof, are provided, as well as methods of using the peptides as natriuretics, diuretics, and/or vasodilators.
Claims26
A compound of formula (I):
- X0-Pro-X1-A5-A1-A3-Pro-A1-Pro-A1-A5-Pro-X1-X1-X1-A4-X2
- wherein A1 is Leu, Lys, Arg, His, Orn, Asn or Gln;
- A3 is Asp or Glu;
- A4 is Lys, Arg, Orn, Ala, Thr, Asn, or Gln;
- A5 is Gly, Ala, Val, Met, Leu, Norleucine or Ile;
- X2 is absent or is a peptide of from 1 to 35 amino acid residues;
- X1 is Ser or Thr;
- X0 is absent or is a peptide of from 1 to 35 amino acid residues;
- wherein X0 is not Glu-Val-Lys-Tyr-Asp-Pro-Cys-Phe-Gly-His-Lys-Ile-Asp-Arg-Ile-Asn-His-Val-Ser-Asn-Leu-Gly-Cys (SEQ ID NO:11);
- and wherein the compound is not SEQ ID NO:1.
7 more elements
A compound which comprises a variant of SEQ ID NO:3, wherein the variant has one or more amino acid substitutions selected from the group consisting of Pro to Gly;
- Ser to Thr;
- Thr to Ser;
- Arg to Lys, Gln or Asn;
- Ala to Val, Ile, or Leu;
- Leu to Nor, Ile, Val, Met, Ala, or Phe;
- Asp to Glu;
- and Asn to Gln, His, Lys or Arg.
4 more elements
A compound which comprises a variant of SEQ ID NO:3, wherein the variant has one or more amino acid substitutions selected from the group consisting of Ser to Thr;
- Thr to Ser;
- Arg to Lys, Gln or Asn;
- Ala to Val, Ile, or Leu;
- Leu to Nor, Ile, Val, Met, Ala, or Phe;
- Asp to Glu;
- and Asn to Gln, His, Lys or Arg.
3 more elements
Dependencies are inferred from the claim text.