Nematode PGM-like sequences
AssigneeDivergence, Inc.
InventorsAndrew P. Kloek, Deryck Jeremy Williams, Brandy Salmon, John D. Bradley
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Abstract
Disclosed is a nucleic acid molecule from nematodes encoding for phosphoglycerate mutase (PGM) polypeptides. The PGM-like polypeptide sequence is also provided, as are vectors, host cells, and recombinant methods for production of PGM-like nucleotides and polypeptides. The invention further relates to screening methods for identifying inhibitors and/or activators, as well as methods for antibody production. Such inhibitors are useful for control nematode infection.
Claims10
An isolated nucleic acid molecule encoding a polypeptide comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:2, wherein the polypeptide has phosphoglycerate mutase activity.
An isolated nucleic acid molecule comprising the nucleotide sequence of nucleotides 22 to 1599 of SEQ ID NO:
- 1.
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.