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US 6,818,185 B1Granted
Cartridge for conducting a chemical reaction
AssigneeCepheid
InventorsKurt E. Petersen, William A. McMillan, Farzad Pourahmadi, Ronald Chang, Douglas B. Dority
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Abstract
A device for conducting a chemical reaction comprises a body having at least first and second channels formed therein. A reaction vessel extends from the body. The reaction vessel has a reaction chamber, an inlet port connected to the reaction chamber via an inlet channel, and an outlet port connected to the reaction chamber via an outlet channel. The inlet port of the vessel is connected to the first channel in the body, and the outlet port of the vessel is connected to the second channel in the body.
Claims50
A device for conducting a chemical reaction, the device comprising:
- a) a body having at least first and second channels formed therein;
- and
- b) a reaction vessel extending from the body, the reaction vessel having:
- i) a rigid frame defining side walls of a reaction chamber;
- ii) first and second polymeric films attached to opposite sides of the rigid frame to form opposing major walls of the reaction chamber;
- iii) an inlet port connected to the reaction chamber via an inlet channel;
- and
- iv) an outlet port connected to the reaction chamber via an outlet channel;
- wherein the inlet port of the vessel is connected to the first channel in the body and wherein the outlet port of the vessel is connected to the second channel in the body.
6 more elements
A device for conducting a chemical reaction, the device comprising:
- a) a body having:
- i) a sample flow path;
- and
- ii) a separation region in the sample flow path for separating a desired analyte from a fluid sample;
- b) a reaction vessel extending from the body, the reaction vessel having:
- i) a reaction chamber;
- ii) an inlet port connected to the reaction chamber via an inlet channel;
- and
- iii) an outlet port connected to the reaction chamber via an outlet channel;
- wherein the body further has at least first and second channels formed therein, the separation region being connected to the inlet port of the vessel via the first channel in the body, and the outlet port of the vessel being connected to the second channel in the body.
7 more elements
A device for conducting a chemical reaction, the device comprising:
- a) a body having at least first and second channels formed therein;
- and
- b) a reaction vessel extending from the body, the reaction vessel having:
- i) a plurality of walls defining a reaction chamber, at least one of the walls comprising a flexible sheet or film;
- ii) an inlet port connected to the reaction chamber via an inlet channel;
- and
- iii) an outlet port connected to the reaction chamber via an outlet channel, wherein the inlet port of the vessel is connected to the first channel in the body, and wherein the outlet port of the vessel is connected to the second channel in the body;
- c) at least one thermal surface for contacting the sheet or film;
- d) means for increasing the pressure in the reaction chamber, wherein the pressure increase in the chamber is sufficient to force the sheet or film to conform to the thermal surface;
- and
- e) at least one thermal element for heating or cooling the surface to induce a temperature change in the chamber.
8 more elements
A device for conducting a chemical reaction, the device comprising:
- a) a body having at least first and second channels formed therein;
- and
- b) a reaction vessel extending from the body, the reaction vessel having:
- i) a rigid frame defining side walls of a reaction chamber;
- ii) first and second polymeric films attached to opposite sides of the rigid frame to form opposing major walls of the reaction chamber;
- wherein at least two of the walls of the reaction chamber are optically transmissive;
- iii) an inlet port connected to the reaction chamber via an inlet channel;
- and
- iv) an outlet port connected to the reaction chamber via an outlet channel, wherein the inlet port of the vessel is connected to the first channel in the body and wherein the outlet port of the vessel is connected to the second channel in the body;
- and
- c) optics for optically interrogating the reaction chamber, the optics comprising at least one light source for transmitting light to the reaction chamber through a first one of the optically transmissive walls and at least one detector for detecting light exiting the chamber through a second one of the optically transmissive walls.
8 more elements
A device for conducting a chemical reaction, the device comprising:
- a) a body having:
- i) a sample flow path;
- and
- ii) a separation region in the sample flow path for separating a desired analyte from a fluid sample;
- b) a reaction vessel extending from the body, the reaction vessel having:
- i) a reaction chamber defined by two opposing major walls and side walls connecting the major walls to each other, at least two of the walls defining the reaction chamber being optically transmissive;
- ii) an inlet port connected to the reaction chamber via an inlet channel;
- and
- iii) an outlet port connected to the reaction chamber via an outlet channel, wherein the body further has at least first and second channels formed therein, the separation region being connected to the inlet port of the vessel via the first channel in the body, and the outlet port of the vessel being connected to the second channel in the body;
- and
- c) optics for optically interrogating the reaction chamber, the optics comprising at least one light source for transmitting light to the reaction chamber through a first one of the optically transmissive walls and at least one detector for detecting light exiting the chamber through a second one of the optically transmissive walls.
8 more elements
Dependencies are inferred from the claim text.