In situ polymerizable hydrogels
AssigneeIncept, LLC
InventorAmarpreet S. Sawhney
Life of this patent
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Abstract
Compositions and methods for forming hydrogels in situ through a combination of physical and chemical crosslinking processes are provided in which physical crosslinking is mediated by one or more natural or synthetic components that stabilize the a hydrogel-forming precursor solutions at a deposition site for a period of time sufficient for more resilient chemical crosslinks to form. Methods of using such hydrogels as tissue coatings to prevent postsurgical adhesion formation, as tissue augmentation or luminal occlusion aids, as matrices for carrying cells, drugs or other bioactive species, as tissue sealants or adhesives, and as medical device coatings also are provided.
Claims32
A hydrogel system for forning a medical implant in situ in a human body, the hydrogel system comprising:
- a first component that forms physical crosslinks to make a water-insoluble gel in situ immediately upon introduction into the human body, and
- a second component that forms chemical crosslinks in situ,
- wherein the physical crosslinks formed by the first component stabilize and confine the second component in situ during formation ofthe chemical crosslinks;
- with the first component including a first polymer that is chosen from the group consisting of a thermoteversible polymer, a hydrophobic thermoreversible polymer, a pH responsive polymer, a composition of polymers with opposite ionic charges, a composition of a poly(alkylene) oxide plus a second polymer that undergoes an association reaction with the poly(alkylene) oxide, a thixotropic polymer, a polymer that gels upon cooling, and a polymer that forms physical crosslinks in response to a divalent cation;
- with the second component including a second polymer that includes chemical groups for forming covalent bonds;
- and
- the second component being a substantially water soluble macromer.
The hydrogel system of clam 1 wberein the first component also fonrs chemical crosslinks by a mechanism selected ftom a group consisting of free radical polymerization, condensation polymerization, anionic or cationic polymerization, and step growth polymerization.
A system for forming a medical implant in a human body in situ comprising:
- a first comoponent and a second component that cooperate in situ;
- comprising:
- the first component including a substantially water soluble precursor that forms a mechanically stable water-insoluble gel in situ stabilized by physical crosslinks;
- with the first component being a first poloymer chosen from the group consisting of a themoreversible polymer, a hydrophobic thermoreversible polymer, a pH responsive polymer, a composition of polymers with opposite ionic charges, a composition of a poly(alkylene) oxide and a polymer that undergoes an association reaction with the poly(alkylene) oxide, a thixotropic polymer, a polymer that gels upon cooling, and a polymer that forms physical crosslinks in response to a divalent cation;
- with the second component being a second polymer including chemical groups for forming covalent bonds wherein the chemical groups include N-hydroxy succinamide esters.
A hydrogel system for forming a medical implant in situ in a human body, the hydrogel system comprising:
- a first component comprising a polymer that is chosen from the group consisting of a thermoreversible polymer and a polymer that forms physical crosslinks in response to a divalent cation;
- and
- a second component that forms chemical crosslinks in situ, with the second component being a substantially water soluble macromer and comprising N-hydroxy succinamide ester chemical groups for forming covalent bonds with nucleophiles.
Dependencies are inferred from the claim text.