Methods for therapy of neurodegenerative disease of the brain
AssigneeThe Regents of the University of California
InventorMark H. Tuszynski
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Abstract
A specific clinical protocol for use toward therapy of defective, diseased and damaged neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative conditions such as Parkinson's disease and Alzheimer's disease. The protocol is practiced by directly delivering a definite concentration of recombinant neurotrophin, into a targeted region of the brain using an expression vector. The neurotrophin is delivered to, or within close proximity of, identified defective, diseased or damaged brain cells. The method stimulates growth of targeted neurons, and reversal of functional deficits associated with the neurodegenerative disease being treated.
Claims14
A method for delivery of a therapeutic neurotrophin to targeted defective, diseased or damaged dopaminergic neurons in the mammalian brain, the method comprising directly delivering a neurotrophic composition, comprising a neurotrophin encoding expression vector, into one or more delivery sites within a region of the brain containing targeted neurons, whereby the neurotrophin is expressed in, or within 500 μm from, a targeted cell, and no more than about 10 mm from another delivery site;
- and wherein further contact with the neurotrophin ameliorates the defect, disease or damage.
Dependencies are inferred from the claim text.