Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same
AssigneesAventis Pharma S.A., The University of British Columbia
InventorsPatrick Benoit, Patrice Denefle, Michel Perricaudet, M. E. Suzanne Lewis, Michael R. Hayden
Life of this patent
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Abstract
Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant viruses, especially for the treatment or prevention of dyslipoproteinemia-related pathologies.
Claims15
A method for treating a patient with dyslipoproteinaemia comprising administering to the patient via intravenous injection a defective recombinant adenovirus comprising a nucleic acid sequence coding for a biologically active human lipoprotein lipase (LPL), wherein the nucleic acid sequence is operably linked to a promoter, and wherein the nucleic acid sequence is expressed so as to cause a reduction of lipoprotein in the patient.
A method for treating a patient with hypertriglyceridaemia comprising administering to the patient via intravenous injection a defective recombinant adenovirus comprising a nucleic acid sequence coding for a biologically active human lipoprotein lipase (LPL) wherein the nucleic acid sequence is operably linked to a promoter, and wherein the nucleic acid sequence is expressed so as to cause a reduction of triglyceride in the patient.
A method for treating a patient with hypercholesterolaemia comprising administering to the patient via intravenous injection a defective recombinant adenovirus comprising a nucleic acid sequence coding for a biologically active human lipoprotein lipase (LPL), wherein the nucleic acid sequence is operably linked to a promoter, and wherein the nucleic acid sequence is expressed so as to cause a reduction of cholesterol in the patient.
A method for treating a patient with hyperlipidaemia comprising administering to the patient via intravenous injection a defective recombinant adenovirus comprising a nucleic acid sequence coding for a biologically active human lipoprotein lipase (LPL), wherein the nucleic acid sequence is operably linked to a promoter, and wherein the nucleic acid sequence is expressed so as to cause a reduction of lipid in the patient.
A method for treating a patient with familial hypertriglyceridaemia comprising administering to the patient via intravenous injection a defective recombinant adenovirus comprising a nucleic acid sequence coding for a biologically active human lipoprotein lipase (LPL) wherein the nucleic acid sequence is operably linked to a promoter, and wherein the nucleic acid sequence is expressed so as to cause a reduction of triglyceride in the patient.
A method for treating a patient with combined familial hyperlipidaemia and postprandial hyperlipidaemia comprising administering to the patient via intravenous injection a defective recombinant adenovirus comprising a nucleic acid sequence coding for a biologically active human lipoprotein lipase (LPL), wherein the nucleic acid sequence is operably linked to a promoter, and wherein the nucleic acid sequence is expressed so as to cause a reduction of lipid in the patient.
Dependencies are inferred from the claim text.