Methods and compositions for treating flaviviruses and pestiviruses

A method for the treatment of a flavivirus or pestivirus infection in a host in need thereof, comprising administering to said host an antivirally effective amount of a β-D nucleoside compound of the structure:

• or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier or diluent.

A method for the treatment of a flavivirus or pestivirus infection in a host in need thereof, comprising administering to said host an antivirally effective amount of a β-D nucleoside compound of the structure:

• or a pharmaceutically acceptable salt or prodrug thereof, optionally in a pharmaceutically acceptable carrier or diluent.

A method for the treatment of a flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

• or a pharmaceutically acceptable salt or ester thereof.

A method for the treatment of a flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

• or a pharmaceutically acceptable salt or ester thereof.

A method for the treatment of a flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

• or a pharmaceutically acceptable salt or ester thereof.

A method for the treatment of a flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

• or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.

A method for the treatment of a flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

• or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier or diluent.

A method for the treatment of a flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

• or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier or diluent.

A method for the treatment of flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

A method for the treatment of flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

A method for the treatment of a flavivirus or pestivirus infection in a human in need thereof, comprising administering to said human an antivirally effective amount of a β-D nucleoside compound of the structure:

A method for the treatment of a flavivirus or pestivirus infection in a host in need thereof, comprising administering to said host an antivirally effective amount of a β-D-2′-C-branched pyrimidine nucleoside.

A method for the treatment of a flavivirus or pestivirus infection in a host in need thereof, comprising administering to said host an antivirally effective amount of a β-D-2′-C-branched pyrimidine ribonucleoside.