Diagnosis and treatment of malignant neoplasms
AssigneeRhode Island Hospital
InventorsJack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
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Abstract
The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
Claims14
A method of inhibiting tumor growth in a mammal comprising administering to said mammal a dominant negative mutant of HAAH, wherein said HAAH comprises the amino acid sequence of SEQ ID NO:2, and wherein said mutant comprises a mutation, said mutation consisting of a substitution or deletion of a single amino acid at residue 679 of SEQ ID NO:2.
A method of inhibiting tumor growth in a mammal comprising administering to said mammal a dominant negative mutant of HAAH, wherein said HAAH comprises the amino acid sequence of SEQ ID NO:2, and wherein said mutant comprises a mutation, said mutation consisting of a substitution or deletion of a single amino acid at residue 690 of SEQ ID NO:2.
A method of inhibiting growth of a tumor in a mammal comprising administering to said mammal an antibody selected from the group consisting of 5C7 produced by hybridoma ATCC designation PTA 3383, 19B produced by hybridoma ATCC designation 3384, and 86A produced by hybridoma ATCC designation 3385.
Dependencies are inferred from the claim text.