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US 6,812,204 B1Granted
Delivery of an agent
AssigneeGendel Limited
InventorsAnthony Patrick McHale, Roger Craig, Ana Maria Rollan Haro
Life of this patent
Estimating the term…
Abstract
The invention relates to a method for selectively releasing an agent loaded into a red blood cell, comprising electrosensitizing the red blood cell by application of an electric field and subsequently disrupting the cell selectively using ultrasound.
Claims18
A method for selectively releasing an agent from a red blood cell comprising the steps of:
- (a) loading the red blood cell with the agent in vitro or ex-vivo;
- (b) sensitising in vitro or ex-vivo the red blood cell by exposing it to an electric field;
- and
- (c) causing the agent to be released from the loaded and sensitised red blood cell by applying ultrasound at a frequency and energy sufficient to cause disruption of the loaded and sensitized red blood cell but insufficient to cause disruption of unsensitised red blood cells.
1 more element
A method for delivering an agent to a target site in a vertebrate, comprising the steps of:
- (a) loading a red blood cell with the agent in vitro or ex-vivo;
- (b) sensitising in vitro or ex-vivo the red blood cell by exposing it to an electric field;
- (c) introducing the loaded and sensitized red blood cell to the target site in a vertebrate by transfusion or infusion;
- and
- (d) causing the agent to be released from the loaded and sensitised red blood cell by applying ultrasound at a frequency and energy sufficient to cause disruption of the loaded and sensitised red blood cell but insufficient to cause disruption of unsensitised red blood cells.
2 more elements
Dependencies are inferred from the claim text.