System and method for high throughput sample preparation and analysis using column chromatography

A system for high throughput sample preparation and analysis using column chromatography, the system comprising:

• a) a plurality of ports, each port having both a port input that interfaces with a first fluid source and a port output;
• b) a fluidic circuit coupled to each port output and to a second fluid source, the fluidic circuit for controlling fluid flow from the plurality of ports and the second fluid source;
• c) a plurality of chromatography columns, each chromatography column coupled to the fluidic circuit;
• d) an interface to an analyzer that receives output from at least one of the plurality of chromatography columns;
• and
• e) a translation stage that allows for movement of the plurality of chromatography columns relative to the analyzer, such that sample output from one of the plurality of chromatography columns can be selectively presented to the analyzer.