Stimulation for delivery of molecular therapy
AssigneeMedtronic, Inc.
InventorsMaura G. Donovan, Orhan Soykan, D. Curtis Deno, Lawrence J. Mulligan, Brian C. A. Fernandes
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Abstract
Provided are novel stimulatory device for the controlled production of angiogenic growth factors. More specifically, a subthreshold pulse generator is used for the local production of vascular endothelial growth factor.
Claims67
A subthreshold pulse generator comprising:
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue;
- wherein the amplitude of the delivered electrical pulse from the power supply has a variable electrical field of about 1 V/cm to about 0.1 V/cm.
A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked with targeted mammalian cells or tissues;
- wherein the subthreshold pulse generator comprises
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue
- wherein further the amplitude of the delivered electrical pulse from the power supply has a variable electrical field of about 1 V/cm to about 0.1 V/cm.
A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked to the tissue for acute subthreshold stimulation therapy to improve angiogenesis;
- wherein the subthreshold pulse generator comprises
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue
- wherein further the amplitude of the delivered electrical pulse from the power supply has a variable electrical field of about 1 V/cm to about 0.1 V/cm.
A method of increasing vascularization in a target tissue comprising providing subthreshold stimulatory pulses to the targeted muscle tissue using the pulse generator;
- wherein the subthreshold pulse generator comprises
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue
- wherein further the amplitude of the delivered electrical pulse from the power supply has a variable electrical field of about 1 V/cm to about 0.1 V/cm.
A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to vascular muscle tissue using the pulse generator;
- wherein the subthreshold pulse generator comprises
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue
- wherein further the amplitude of the delivered electrical pulse from the power supply has a variable electrical field of about 1 V/cm to about 0.1 V/cm.
A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to heart muscle tissue using the pulse generator;
- wherein the subthreshold pulse generator comprises
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue
- wherein further the amplitude of the delivered electrical pulse from the power supply has a variable electrical field of about 1 V/cm to about 0.1 V/cm.
A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to skeletal muscle tissue using the pulse generator;
- wherein the subthreshold pulse generator comprises
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue
- wherein further the amplitude of the delivered electrical pulse from the power supply has a variable electrical field of about 1 V/cm to about 0.1 V/cm.
A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked to a muscle tissue for subthreshold stimulation therapy using the pulse generator;
- wherein the subthreshold pulse generator comprises
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue
- wherein further the amplitude of the delivered electrical pulse from the power supply has a variable electrical field of about 1 V/cm to about 0.1 V/cm.
A method of improving vascularization in a targeted tissue comprising the steps of:
- a. stimulating cultured cells with a subthreshold electrical field using the pulse generator;
- wherein the pulse generator comprises
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a variable electric field of about 1 V/cm to about 0.1 V/cm;
- and then subsequently
- b. injecting the stimulated cells into the targeted body tissue.
A method of improving vascularization in a targeted tissue comprising the steps of:
- a. injecting cells into a targeted body tissue;
- and
- b. stimulating the injected cell area with subthreshold stimulation using the pulse generator wherein the pulse generator comprises:
- (a) a power supply;
- and
- (b) a control mechanism interconnected with the power supply to deliver a variable electric field of about 1 V/cm to about 0.1 V/cm.
Dependencies are inferred from the claim text.