Stent for keeping open tubular structures
AssigneeMagForce Applications GmbH
InventorAndreas Jordan
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Abstract
A stent made of metallic and/or non-metallic material that can be implanted into tubular structures or other body cavities is coated with nanoscale particles that consist of a paramagnetic core and at least one shell adsorbed to it which is durably bonded to the stent surface. This coating makes it possible to selectively and homogeneously heat up the implant by applying an alternating magnetic field with a clinically tolerable combination of field strength and frequency, thereby achieving high power absorption and, on the one hand, a temperature level that enhances the growing-in of the implant by enhancing cell proliferation, on the other hand, a temperature range in which a restenosed implant can be regenerated. Also, it facilitates position detection.
Claims14
A stent for keeping open tubular structures and restenosis prevention by heating, said stent comprising a tube-shaped support made of one of a metallic and a non-metallic material coated with nanoscale particles, with each nanoscale particle including a paramagnetic core and at least one shell that adheres to said stent for position detection by MR tomography and for homogeneous and controlled heating and power absorption in an alternating magnetic field with a specific field strength and frequency suitable for clinical use, wherein:
- each nanoscale particle consists of one of a ferromagnetic, ferrimagnetic and supramagnetic core;
- said shell surrounds and adsorbs to said core;
- and
- said shell comprises reactive groups formed from monomeric aminosilanes capable of forming cationic groups that are degraded so slowly by body tissue that said shell durably bonds to said stent when said stent is in contact with the body tissue.
Dependencies are inferred from the claim text.