Device and method for delivering or withdrawing a substance through the skin

An apparatus for delivering or withdrawing a fluid through at least one layer of the skin of a subject, the apparatus comprising:

• a device comprising
• a body having a top face, a bottom face spaced from the top face, and a side edge, the body defining at least one channel,
• wherein the bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area, the bottom face further including at least one raised protrusion disposed on the second surface area, the at least one raised protrusion having a height from the first surface, and the height being greater than the first distance;
• at least one dermal-access member provided in the at least one raised protrusion and being in fluid communication with the channel to deliver or withdraw the fluid, the at least one dermal-access member extending at least 1 mm from the at least one protrusion;
• and
• means for driving the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.