Modulated chemical shift imaging solvent suppression
AssigneeGE Medical Systems Global Technology Company, LLC
InventorDavid H. Gurr
Life of this patent
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Abstract
A technique is provided whereby a solvent spectrum may be partially modulated from a spectrum of interest using magnetic resonance spectroscopic imaging. The technique utilizes a solvent suppression technique capable of variable levels of suppression and alternates the application of first and second suppressive pulses in the imaging sequence which differ in the degree of solvent suppression they produce. The alternation of these suppressive pulses results in the partial modulation of the solvent signal from the signal of interest after processing.
Claims24
A method of partially modulating a solvent spectrum from one or more spectra of interest, comprising:
- alternately applying a first imaging pulse sequence preceded by a first solvent suppressing pulse and a second imaging pulse sequence preceded by a second solvent suppressing pulse to a sample, wherein the first solvent suppressing pulse suppresses a solvent spectrum by a first amount and the second solvent suppressing pulse suppresses the solvent spectrum by a different amount.
A method of forming a magnetic resonance spectroscopic image, comprising:
- iteratively applying an imaging pulse sequence to a subject, wherein the imaging pulse sequence is alternately preceded by a first solvent suppressive pulse and a second solvent suppressive pulse which differ in the amount of solvent suppression they produce;
- acquiring a resonance data set resulting from each imaging pulse sequence before applying the subsequent imaging pulse sequence;
- forming an acquisition matrix from the resonance data sets;
- processing the acquisition matrix;
- and
- constructing a spectroscopic image from the processed matrix.
A magnetic resonance spectroscopy imaging system, comprising:
- a magnetic resonance scanner;
- one or more control and acquisition circuits operably connected to the scanner;
- system controller circuitry operably connected to the one or more control and acquisition circuits, wherein the system controller circuitry is configured to iteratively apply an imaging pulse sequence to a subject, wherein the imaging pulse sequence is alternately preceded by a first solvent suppressive pulse and a second solvent suppressive pulse which differ in the amount of solvent suppression they produce, to acquire a resonance data set resulting from each imaging pulse sequence before applying the subsequent alternating imaging pulse sequence, and to process the resonance data sets to produce one or more spectra of interest;
- and
- an operator interface station operably connected to the system controller circuitry.
A computer program for partially modulating a solvent spectrum relative to one or more spectra of interest, comprising:
- a machine readable medium for supporting machine readable code;
- and
- configuration code stored on the machine readable medium for applying two or more imaging pulse sequences to a subject, wherein the imaging pulse sequences are alternately preceded by a first solvent suppressive pulse and a second solvent suppressive pulse which differ in the amount of solvent suppression they produce.
A magnetic resonance spectroscopy imaging system, comprising:
- a magnetic resonance scanner;
- one or more control and acquisition circuits operably connected to the scanner;
- system controller circuitry operably connected to the one or more control and acquisition circuits, wherein the system controller circuitry comprises means for producing a magnetic resonance spectroscopic image in which a solvent spectrum is partially modulated from one or more spectra of interest;
- and
- an operator interface station operably connected to the system controller circuitry.
Dependencies are inferred from the claim text.