Process for preparation of allyl sulfone derivatives and intermediates for the preparation
AssigneeSumitomo Chemical Company, Limited
InventorsToshiya Takahashi, Hirotada Kakiya, Shinzo Seko
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for producing an allyl sulfone derivative represented by the formula (3): wherein Ar is an optionally substituted aryl group, and the corrugated line means either one of E/Z geometrical isomers, or a mixture thereof, which is an intermediate for producing vitamin A, which process is characterized by reacting an aryl sulfinic acid or a salt thereof represented by the formula (2): ArSO2M (2) wherein Ar is as defined above, and M is hydrogen atom, sodium atom or potassium atom, with an allyl halide derivative represented by the formula (1): wherein X is a halogen atom, and Ar and the corrugated line are as defined above.
Claims23
An allyl halide compound represented by the formula (1):
- wherein Ar is an optionally substituted aryl group, X is a halogen atom, and the corrugated line means either one of E/Z geometrical isomers or a mixture thereof.
A process for producing an allyl sulfone compound represented by the formula (3):
- wherein Ar is an optionally substituted aryl group, and the corrugated line means either one of E/Z geometrical isomers or a mixture thereof, which comprises reacting an aryl sulfinic acid or a salt thereof represented by the formula (2):
- ArSO2M (2)
- wherein Ar is as defined above, and M is hydrogen atom, sodium atom or potassium atom, with an allyl halide compound represented by the formula (1):
- wherein x is a halogen atom, and Ar and the corrugated line are as defined above.
A process for producing an allyl sulfone compound represented by the formula (3):
- wherein Ar is an optionally substituted aryl group, and the corrugated line means either one of E/Z geometrical isomers or a mixture thereof, which comprises reducing an aryl sulfonyl chloride represented by the formula (4):
- ArSO2Cl (4)
- wherein Ar is as defined above to obtain an aryl sulfinic acid or a salt thereof represented by the formula (2):
- ArSO2M (2)
- wherein Ar is as defined above, and M is hydrogen atom, sodium atom or potassium atom, followed by, without isolation, reacting it with an allyl halide compound represented by the formula (1):
- wherein X is a halogen atom, and Ar and the corrugated line are as defined above.
Dependencies are inferred from the claim text.