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US 6,806,373 B2Granted
Process for preparing leflunomide form I
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsIiya Avrutov, Neomi Gershon, Judith Aronhime
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Abstract
New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositions and dosage forms containing the new form and methods of using them for the treatment of rheumatoid arthritis are also disclosed.
Claims6
A process for preparing leflunomide Form I comprising the steps of
- a) heating crystals of leflunomide Form III for a period of time sufficient to transform the Form III crystals into leflunomide Form I and
- b) recovering crystals of leflunomide Form I.
Dependencies are inferred from the claim text.