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US 6,806,358 B1Granted
Peptide inhibitor of TGF-β growth factors
AssigneeUniversity of California, San Diego
InventorsEthan Bier, Kweon Yu
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Abstract
A potent peptide inhibitor (SuperSog) of TGF-β family growth factor signalling, peptide variants thereof and nucleotide coding sequences therefor are provided by the invention. The Super-Sog peptide comprises a fragment of the Drosophilia short gastrulation (Sog) gene which includes the CR-1 cysteine-rich repeat of Sog. Methods and compositions for use of Super-Sog in therapeutic and diagnostic applications are also provided.
Claims2
An isolated or purified polynucleotide encoding a polypeptide consisting of amino acids 1-292 of the Drosophilia Sog protein.
Dependencies are inferred from the claim text.