Secreted and transmembrane polypeptides and nucleic acids encoding the same
AssigneeGenentech, Inc.
InventorsLuc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
Life of this patent
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Abstract
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims12
An isolated polypeptide having at least 80% amino acid sequence identity to:
- (a) the ammo acid sequence of the polypeptide shown in FIG. 48 (SEQ ID NO:132);
- (b) the amino acid sequence of the polypeptide shown in FIG. 48 (SEQ ID NO:132), lacking its associated signal peptide;
- (c) the amino acid sequence of the extracellular domain of the polypeptide shown in FIG. 48 (SEQ ID NO:132);
- (d) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209251;
- wherein, the polypeptide is capable of inducing chondrocyte redifferentiation.
An isolated polypeptide comprising:
- (a) the amino acid sequence of the polypeptide shown FIG. 48 (SEQ ID NO:132);
- (b) the amino acid sequence of the polypeptide shown in FIG. 48 (SEQ ID NO:132), lacking its associated signal peptide;
- (c) the amino acid sequence of the extracellular domain of the polypeptide shown in FIG. 48 (SEQ ID NO:132);
- (d) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209251;
- wherein, the polypeptide is capable of inducing chondrocyte redifferentiation.
Dependencies are inferred from the claim text.