Analgesic compounds, their synthesis and pharmaceutical compositions containing them
AssigneeThe Foundation for the LSU Health Sciences Center
InventorsCarlos Sunkel, Julio Alvarez-Builla, Nicolas G. Bazan, Anthony Vaccarino
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Abstract
New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepatotoxic effect, making them more useful than conventional non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of chronic pain.
Claims17
A substantially pure compound of the formula II,
- wherein n is a number from 1 to 5.
A process for preparing a compound of formula II,
- comprising:
- reacting a compound of formula I, wherein n is a number from 1 to 5,
- with aqueous sodium hydroxide, to give a compound of formula II.
An analgesic composition comprising, safe, and pharmaceutically effective amounts of:
- (a) an opioid analgesic;
- (b) a non-narcotic analgesic of the general formula,
- wherein n is a number from 1 to 5;
- and
- (c) a pharmaceutically acceptable carrier.
An analgesic composition comprising synergistic, safe, and pharmaceutically effective amounts of:
- (a) a non-opioid analgesic;
- (b) a non-narcotic analgesic of the general formula,
- wherein n is a number from 1 to 5;
- and
- (c) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.