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US 6,806,289 B1Granted
Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same
OwnerStephen J. Lippard, Christopher J. Zieglerinventors
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Abstract
The present invention provides novel coordination complexes, methods for synthesizing and identifying coordination complexes using combinatorial techniques, and assaying for their activity. In certain embodiments, the subject coordination complexes contain platinum,
Claims25
A coordination complex, comprising:
- a structure represented by the formula:
- wherein, independently for each occurrence:
- X represents halogen or other labile ligand;
- W represents S, N, or P;
- Y represents —OR7, —SR7, a halogen or —N(R9)R10;
- R9 and R10, each independently, represent —H, alkyl, alkenyl, —(CH2)n—R7, or R9 and R10, taken together with the N atom to which they are attached complete a heterocycle having from 4 to about 8 atoms in the ring structure, all optionally substituted;
- L represents a non-labile ligand;
- and
- R7 represents —H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycle or polycycle;
- and
- the ligand V comprises a heterocycle, optionaly aromatic and optionally substituted, that comprises W and Y and has from 4 to about 8 atoms in the ring structure;
- and wherein the symbol represents a single or a double bond.
9 more elements
A coordination complex, comprising:
- a structure represented by the formula:
- wherein, independently for each occurrence:
- X represents halogen or other labile ligand;
- W represents S, N, or P;
- Y represents —OR7, —SR7, a halogen or —N(R9)R10;
- R9 and R10, each independently, represent —H, alkyl, alkenyl, —(CH2)m—R7, or R9 and R10;
- taken together with the N atom to which they are attached complete a heterocycle having from 4 to about 8 atoms in the ring structure, all optionally substituted;
- L represents a non-labile ligand;
- and
- R7 represents —H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycle or polycycle;
- and the ligand V comprises a heterocycle, optionally aromatic and optionally substituted, that comprises W and Y and has from 4 to about 8 atoms in the ring structure;
- and wherein the symbol represents a single or a double bond.
9 more elements
A coordination complex, comprising:
- a structure represented by the formula:
- where, in independently for each occurrence:
- X represents halogen or other labile ligand;
- W represents S, N, or P;
- Y represents —OR7, —SR7, a halogen or —N(R9)R10 ;
- R9 and R10, each independently, represent —H, alkyl, alkenyl, —(CH2)n—R7, or R9 and R10, taken together with the N atom to which they are attached complete a heterocycle having from 4 to about 8 atoms in the ring structure, all optionally substituted;
- L represents a non-labile ligand;
- and
- R7 represents —H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycle or polycycle;
- and the ligand V comprises a heterocycle, optionally aromatic and optionally substituted, that comprises W and Y and has from 4 to about 8 atoms in the ring structure.
- and wherein the symbol represents a single or a double bond.
8 more elements
Dependencies are inferred from the claim text.