Substituted benzopyran derivatives for the treatment

A compound of Formula I

• wherein X is S;
• wherein Ra is alkyl;
• wherein R is selected from carboxyl, aminocarbonyl, alkylsulfonylaminocarbonyl and alkoxycarbonyl;
• wherein R1 is selected from haloalkyl, alkyl, aralkyl, cycloalkyl and aryl optionally substituted with one or more radicals selected from alkylthio, nitro and alkylsulfonyl;
• and
• wherein R2 is one or more radicals selected from hydrido, halo, alkyl, aralkyl, alkoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralky!oxy, haloalkyl, haloalkoxy, alkylamino, arylamino, aralkylamino, heteroarylamino, heteroarylalkylamino, nitro, amino, aminosulfonyl, alkylaminosulfonyl, arylaminosulfonyl, heteroarylaminosulfonyl, aralkylaminosulfonyl, heteroaralkylaminosulfonyl, heterocyclosulfonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heteroaryl, aralkylcarbonyl, heteroarylcarbonyl, arylcarbonyl, aminocarbonyl, and alkylcarbonyl;
• or wherein R2 together with ring A forms a naphthyl radical;
• or an isomer or pharmaceutically acceptable salt thereof.

A compound of Formula II

• wherein X is S;
• wherein R2 is lower haloalkyl;
• wherein R3 is selected from hydrido, and halo;
• wherein R4 is selected from hydrido, halo, lower alkyl, lower haloalkoxy, lower alkoxy, lower aralkylcarbonyl, lower dialkylaminosulfonyl, lower alkylaminosulfonyl, lower aralkylaminosulfonyl, lower heteroaralkylaminosulfonyl, and 5- or 6-membered nitrogen-containing heterocyclosulfonyl;
• wherein R5 is selected from hydrido, lower alkyl, halo, lower alkoxy, and aryl;
• and
• wherein R6 is selected from hydrido, halo, lower alkyl, lower alkoxy, and aryl;
• or an isomer or pharmaceutically acceptable salt thereof.

A compound of Formula IIb:

• wherein R3 is selected from hydrido, lower alkyl, lower hydroxyalkyl, lower alkoxy and halo;
• wherein R4 is selected from hydrido, halo, lower alkyl, lower alkylthio, lower haloalkyl, amino, aminosulfonyl, lower alkylsulfonyl, lower alkylsulfinyl, lower alkoxyalkyl, lower alkylcarbonyl, formyl, cyano, lower haloalkylthio, substituted or unsubstituted phenylcarbonyl, lower haloalkoxy, lower alkoxy, lower aralkylcarbonyl, lower dialkylaminosulfonyl, lower alkylaminosulfonyl, lower aralkylaminosulfonyl, lower heteroaralkylaminosulfonyl, 5- or 6-membered heteroaryl, lower hydrooxyalkyl, optionally substituted phenyl and 5- or 6-membered nitrogen containing heterocyclosulfonyl;
• wherein R5 is selected from hydrido, lower alkyl, halo, lower haloalkyl, lower alkoxy, and phenyl;
• and wherein R6 is selected from hydrido, halo, cyano, hydrooxyiminomethyl, lower hydroxyalkyl, lower alkynyl, phenylalkynyl, lower alkyl, lower alkoxy, formyl and phenyl;
• or an isomer or pharmaceutically acceptable salt thereof.