Arylpiperidine derivatives and use thereof
AssigneesNihon Nohyaku Co., Ltd., Taisho Pharmaceutical Co., Ltd.
InventorsMasashi Nagamine, Makoto Gotoh, Masanori Yoshida, Atsuro Nakazato, Toshihito Kumagai, Shigeyuki Chaki, Kazuyuki Tomisawa
Life of this patent
Estimating the term…
Abstract
The present invention provides an arylpiperidine derivative of the formula (I) or a pharmaceutically acceptable salt thereof, which has antipsychotic effect: wherein D is a carbon atom or a nitrogen atom, E is a CH group or a nitrogen atom, G is an oxygen atom, a sulfur atom, a nitrogen atom or an NH group, Y1 is a hydrogen atom or a halogen atom, n is an integer of 1 to 4, and R1 is a group represented by any of the formulas (i) to (iv) defined in the specification.
Claims7
An arylpiperidine compound represented by the formula (I):
- (wherein D is a carbon atom or a nitrogen atom, E is a CH group or a nitrogen atom, G a nitrogen atom Y1 is a hydrogen atom, n is an integer of 1 to 4, and R1 is a group represented by
- the formula (ii):
- (wherein R3 is an alkyl group of 1 to 5 carbon atoms, each of X1 and X2, which are different from each other, is a nitrogen atom or an NH group, and Ar is optionally substituted phenyl where the optional substituents are nonheter ocyclic moieties),
- (wherein X1 and X2 are as defined above, and Ar is a substituted or unsubstituted phenyl group or a thienyl group), or a group represented by the formula (iv):
- (wherein R4 is a hydrogen atom, a mercapto group, or an alkylthio group of 1 to 5 carbon atoms, and Ar is a substituted or unsubstituted phenyl group or a thienyl group)) or a pharmaceutically acceptable salt thereof.
An arylpiperidine derivative represented by the formula (II):
- (wherein D is a carbon atom or a nitrogen atom, E is a CH group or a nitrogen atom, G is an oxygen atom, a sulfur atom, a nitrogen atom or an NH group, Y1 is a hydrogen atom or a halogen atom, n is an integer of 1 to 4, R2 is a hydrogen atom, an alkyl group of 1 to 5 carbon atoms, an amino group, a monoalkylamino group of 1 to 5 carbon atoms, a hydroxyl group, an alkoxycarbonyl group of 2 to 6 carbon atoms, a carbamoyl group, a carboxyl group, or a metal salt of carboxyl group, and Ar is a substituted or unsubstituted phenyl group or a thienyl group) or a pharmaceutically acceptable salt thereof.
An arylpiperidine derivative represented by the formula (III):
- (wherein each of Y1 and Y2 is a hydrogen atom or a halogen atom, R5 is an alkyl group of 1 to 5 carbon atoms, an amino group or a carbamoyl group, and J is an oxygen atom, a sulfur atom or an NH group) or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.