Compounds

A compound of general formula

• wherein R1 represents a hydrogen atom, or a group —NR3R4;
• R3 and R4 each independently represent a hydrogen atom, or a 4-piperidinyl, C3-C6 cycloalkyl or C1-C8 alkyl group, which latter two groups are optionally substituted by one or more substituent groups independently selected from halogen atoms and —NR5R6, —CONR5R6, —OR7, —COOR7, —NR8COR9, —SR10, —SO2R10, —SO2NR5R6, —NR8SO2R9, morpholinyl, C1-C4 alkyl, C3-C8 cycloalkyl, tetrahydrofuranyl and aryl groups, wherein an aryl substituent group is optionally a phenyl, naphthyl, thienyl, pyridinyl, imidazolyl or indolyl group, each of which is optionally substituted by one or more substituents independently selected from halogen atoms and cyano, nitro, —NR5R6, —CONR5R6, —OR7, —NR8COR9, —SO2NR5R6, —NR8SO2R9, C1-C6 alkyl and trifluoromethyl groups, or R3 and R4 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring system, which ring system is optionally substituted by one or more substituent groups independently selected from
• —NR5R6, —CONR5R6, —OR7, —COOR10, —NR8COR9, and C1-C6 alkyl optionally substituted by one or more substituents independently selected from halogen atoms and —NR11R12 and —OR7 groups;
• X represents a group —OH or —NR13R14;
• R13 and R14 each independently represent a hydrogen atom, a 4-piperidinyl group optionally substituted by a C1-C4 alkylphenyl substituent group, or a C3-C7 carbocyclic, C1-C8 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group, which latter four groups are optionally substituted by one or more substituent groups independently selected from halogen atoms and —NR5R6, —CONR5R6, —OR7, —COOR7, —NR8COR9, SR10, —SO2R10, —SO2NR5R6, —NR8SO2R9, morpholinyl, C1-C4 alkyl, C3-C6 cycloalkyl and aryl groups, wherein an aryl substituent group is optionally a phenyl, naphthyl, thienyl, pyridinyl, imidazolyl or indolyl group, each of which is optionally substituted by one or more substituents independently selected from halogen atoms and cyano, nitro, —NR5R6, —CONR5R6, —OR7, —NR8COR9, —SO2NR5R6, NR8SO2R9, C1-C6 alkyl and trifluoromethyl groups,
• or R13 and R14 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring system, which ring system is optionally substituted by one or more substituent groups independently selected from —NR5R6, —CONR5R6, —OR7, —COOR7, —NR8COR9, and C1-C6 alkyl optionally substituted by one or more substituents independently selected from halogen atoms and phenyl, —NR11R12 and —OR7 groups;
• R2 represents a C1-C6 alkyl or C2-C6 alkenyl group optionally substituted by a phenyl or phenoxy group, wherein the phenyl or phenoxy group is itself optionally substituted by one or more substituents independently selected from halogen atoms and nitro, C1-C6 alkyl, trifluoromethyl, —OR7, —C(O)R7, —SR10, —NR15R16 and phenyl groups;
• R5 and R6 each independently represent a hydrogen atom or a C1-C6 alkyl or phenyl group, each of which is optionally substituted by one or more substituent groups independently selected from halogen atoms, phenyl, —OR17 and —NR15R16, or R5 and R6 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring system optionally comprising a further heteroatom selected from oxygen and nitrogen atoms, which ring system is optionally substituted by one or more substituent groups independently selected from phenyl, —OR17—COOR17, —NR15R16, —CONR15R16, —NR15COR16, —SONR15R16, and C1-C6 alkyl optionally substituted by one or more substituents independently selected from halogen atoms and —NR15R16 and —OR17 groups;
• R7 and R9 each independently represent a hydrogen atom or a C1-C6 alkyl or phenyl group, each of which is optionally substituted by one or more substituent groups independently selected from halogen atoms, phenyl, —OR17 and —NR15R16;
• and
• each of R8, R10, R11, R12, R15, R16 and R17 independently represents a hydrogen atom or a C1-C6 alkyl or phenyl group;
• with the proviso that when R1 and X both represent —NH2, then R2 does not represent a methyl group;
• or a pharmaceutically acceptable salt or solvate or tautomer thereof.