US 6,806,269 B1Granted

2-Amino-benzoxazinones for the treatment of herpes simplex virus

AssigneeG. D. Searle & Cop

InventorsMasashi Kawanishi, Wataru Takahashi

Life of this patent

Estimating the term…

Abstract

2-Amino-benzoxazinones are identified for use in the treatment of Herpes Simplex Virus. A subject is treated for Herpes Simplex Virus by treating with an effective amount of 2-amino-benzoxazinones

Claims3

Dependent claims

A compound selected from compounds and their pharmaceutically-acceptable salts, of the group consisting of:

6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl(phenylmethyl)-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl[(4-methoxyphenyl)-methyl]amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[1-(1,2,3,6-tetrahydro-pyridyl)]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[isopropyl(methyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-furoyl)piperazinyl]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[[(2-cyano)ethyl]-(cyclopropyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-thenoyl)piperazinyl]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-benzenesulfonyl)-piperazinyl]-4H-3,1-benzoxazin-4-one;
6-(benzoylamino)-5-methyl-2-[methyl(phenylmethyl)amino]-4H-3,1-benzoxazin-4-one;
6-[(phenylmethoxyacetyl)amino]-5-methyl-2-(diisopropylamino)-4H-3,1-benzoxazin-4-one;
6-[(2,4,6-Trifluorobenzoyl)amino]-5-methyl-2(diisopropylamino)-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[[methyl(4-dimethylamino)-phenylmethyl]-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl(2-pyridylmethyl)-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl[2-(3-indolyl)ethyl]amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-(4-morpholyl)-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[allyl(methyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-(1-decahydroquinolyl)-4H-3,1-benzoxazin-4-one;
and
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[4-(1-acetylpiperadinyl)]-4H-3,1-benzoxazin-4-one.

16 more elements

A method or therapeutic or prophylactic treatment of Herpes Simplex Virus in a subject, said method comprising treating said subject with an effective amount of a compound selected from compounds and their pharmaceutically-acceptable salts, of the group consisting of:

6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl(phenylmethyl)-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl[(4-methoxyphenyl)-methyl]amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[1-(1,2,3,6-tetrahydro-pyridyl)]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[isopropyl(methyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-furoyl)piperazinyl]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl)amino]-5-methyl-2-[[(2-cyano)ethyl]-(cyclopropyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-thenoyl)piperazinyl]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-benzenesulfonyl)-piperazinyl]-4H-3,1-benzoxazin-4-one;
6-(benzoylamino)-5-methyl-2-[methyl(phenylmethyl)amino]-4H-3,1-benzoxazin-4-one;
6-[(phenylmethoxyacetyl)amino]-5-methyl-2-(diisopropylamino)-4H-3,1-benzoxazin-4-one;
6-[(2,4,6-Trifluorobenzoyl)amino]-5-methyl-2(diisopropylamino)-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[[methyl(4-dimethylamino)-phenylmethyl]-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl(2-pyridylmethyl)-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl[2-(3-indolyl)ethyl]amino]4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-(4-morpholyl)-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[allyl(methyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,-Dimethylethoxy)carbonyl]amino]-5-methyl-2-(1-decahydroquinolyl)-4H-3,1-benzoxazin-4-one;
and
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[4-(1-acetylpiperadinyl)]-4H-3,1-benzoxazin-4-one.

16 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/030,414Filed 24 May 2002 · us provisional application
Priority: 12 Jul 1999
Granted: 19 Oct 2004
Term ends: Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07D 413/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
C07D 265/24
Condensed with one six-membered ring: with hetero atoms directly attached in positions 2 and 4
C07D 413/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D
Heterocyclic compounds

Family

Application60/142,956Us provisional application · filed 12 Jul 1999
US 6,806,269 B1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

2-Amino-benzoxazinones are identified for use in the treatment of Herpes Simplex Virus. A subject is treated for Herpes Simplex Virus by treating with an effective amount of 2-amino-benzoxazinones

A compound selected from compounds and their pharmaceutically-acceptable salts, of the group consisting of:

6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl(phenylmethyl)-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl[(4-methoxyphenyl)-methyl]amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[1-(1,2,3,6-tetrahydro-pyridyl)]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[isopropyl(methyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-furoyl)piperazinyl]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[[(2-cyano)ethyl]-(cyclopropyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-thenoyl)piperazinyl]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[(4-benzenesulfonyl)-piperazinyl]-4H-3,1-benzoxazin-4-one;
6-(benzoylamino)-5-methyl-2-[methyl(phenylmethyl)amino]-4H-3,1-benzoxazin-4-one;
6-[(phenylmethoxyacetyl)amino]-5-methyl-2-(diisopropylamino)-4H-3,1-benzoxazin-4-one;
6-[(2,4,6-Trifluorobenzoyl)amino]-5-methyl-2(diisopropylamino)-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[[methyl(4-dimethylamino)-phenylmethyl]-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl(2-pyridylmethyl)-amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[methyl[2-(3-indolyl)ethyl]amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-(4-morpholyl)-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[allyl(methyl)amino]-4H-3,1-benzoxazin-4-one;
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-(1-decahydroquinolyl)-4H-3,1-benzoxazin-4-one;
and
6-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methyl-2-[4-(1-acetylpiperadinyl)]-4H-3,1-benzoxazin-4-one.

16 more elements

Facts

Application

10/030,414Filed 24 May 2002 · us provisional application

Priority

12 Jul 1999

Granted

19 Oct 2004

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07D 413/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
C07D 265/24
Condensed with one six-membered ring: with hetero atoms directly attached in positions 2 and 4
C07D 413/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D
Heterocyclic compounds