2-ethyl and 2-ethylidene-19-nor-vitamin D compounds
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Rafal R. Sicinski
Life of this patent
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Abstract
Biologically active 19-nor vitamin D analogs substituted at C-2 in the A-ring with an ethylidene or an ethyl group. These compounds have preferential activity on mobilizing calcium from bone and either high or normal intestinal calcium transport activity which allows their in vivo administration for the treatment of metabolic bone diseases where bone loss is a major concern. These compounds are also characterized by high cell differentiation activity.
Claims56
19-nor-2α-ethyl-1α,25-dihydroxyvitamin D3.
19-nor-2β-ethyl-1α,25-dihydroxyvitamin D3.
19-nor-20(S)-2α-ethyl-1α,25-dihydroxyvitamin D3.
19-nor-20(S)-2β-ethyl-1α,25-dihydroxyvitamin D3.
19-nor-2(E)-ethylidene-1α,25-dihydroxyvitamin D3.
19-nor-2(Z)-ethylidene-1α,25-dihydroxyvitamin D3.
19-nor-2(E)-ethylidene-20(S)-1α,25-dihydroxyvitamin D3.
19-nor-2(Z)-ethylidene-20(S)-1α,25-dihydroxyvitamin D3.
A pharmaceutical composition containing 19-nor-2α-ethyl-1α,25-dihydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
A pharmaceutical composition containing 19-nor-2β-ethyl-1α,25-dihydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
A pharmaceutical composition containing 19-nor-20(S)-2α-ethyl-1α,25-dihydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
A pharmaceutical composition containing 19-nor-20(S)-2β-ethyl-1α,25-dihydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
A pharmaceutical composition containing 19-nor-2(E)-ethylidene-1α,25-dihydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
A pharmaceutical composition containing 19-nor-2(Z) -ethylidene-1α,25-dihydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
A pharmaceutical composition containing 19-nor-2(E) -ethylidene-20(S)-1α,25-dihydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
A pharmaceutical composition containing 19-nor-2(Z) -ethylidene-20(S)-1α,25-dihydroxyvitamin D3 together with a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.