Methods for treating certain diseases using naaladase inhibitors
AssigneeGuilford Pharmaceuticals Inc.
InventorsBarbara S. Slusher, Xi-Chun May Lu, Krystyna Wozniak
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Abstract
The present invention relates to methods for regulating the release of TGF-β from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to be useful for affecting neuroregeneration, cell proliferation, cell differentiation, extracellular matrix formation, myelination, inflammation, immune function, liver function, pancreatic function, angiogenesis, or wound healing; and/or for preventing or treating diabetes.
Claims18
A method of treating an allergy in a mammal, which comprises administering an effective amount of a NAALADase inhibitor to the mammal in need of such treatment.
A method of treating an inflammatory disease due to injury in a mammal, which comprises administering an effective amount of a NAALADase inhibitor to the mammal in need of such treatment.
Dependencies are inferred from the claim text.