Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators
AssigneeBoard of Trustees of Southern Illinois University
InventorsTony Jer-Fu Lee, Chen Ling Ling Yang
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Abstract
The present invention is directed to a method for inhibiting expression of either iNOS or COX-2, or both in mammals using flavone compounds, and pharmaceutically acceptable salts thereof. The present invention is also directed to a method of activating K+ channels in mammals; as well as methods for treating septic shock, for inhibiting expression of angiotensin converting enzyme, for treating or preventing aneurysms and for reducing inflammation and related pathological changes using these compounds. Presently preferred compounds are oroxylin A (5,7-dihydroxy-6-methoxy flavone) and wogonin (5,7-dihydroxy-8-methoxy flavone).
Claims50
A method for inhibiting expression of inducible nitric oxide synthase comprising administering to a mammal in need thereof an effective nitric oxide synthase-inhibiting amount of a flavone and pharmaceutically acceptable salts thereof.
A method for inhibiting expression of cyclooxygenase-2 comprising administering to a mammal in need thereof an effective cyclooxygenase-2-inhibiting amount of a flavone and pharmaceutically acceptable salts thereof.
A method for inhibiting expression of cyclooxygenase-2 and inducible nitric oxide synthase comprising administering to a mammal in need thereof an effective cyclooxygenase-2-and-nitric oxide synthase-inhibiting amount of a flavone and pharmaceutically acceptable salts thereof.
A method for activating potassium channels comprising administering to a mammal in need thereof an effective potassium channel activating amount of a flavone and pharmaceutically acceptable salts thereof.
A method for treating septic shock comprising administering to a mammal in need thereof a therapeutically effective amount of a flavone having one alkoxy group and pharmaceutically acceptable salts thereof.
A method for reducing inflammation comprising administering to a mammal in need thereof an inflammation-reducing amount of a flavone and pharmaceutically acceptable salts thereof.
A method for inhibiting expression of angiotensin converting enzyme comprising administering to a mammal in need thereof an effective angiotensin converting enzyme-inhibiting amount of a flavone and pharmaceutically acceptable salts thereof.
A method for treating or preventing aneurysms comprising administering to a mammal in need thereof a pharmaceutically effective amount of a flavone or a pharmaceutically acceptable salt thereof.
A method of treating septic shock in a patient comprising:
- (a) giving the patient an effective amount of an inhibitor of the iNOS enzyme;
- (b) giving the patient an effective amount of an inhibitor of the synthesis of at least one of the iNOS enzyme and the COX-2 enzyme;
- and
- (c) maintaining suppression of the iNOS or COX-2 enzyme until the cause of the septic shock is removed or overcome.
A method of treating chronic inflammation comprising
- (a) giving the patient an effective amount of an inhibitor of the COX-2 enzyme;
- (b) giving the patient an effective amount of an inhibitor of the synthesis of the synthesis of the iNOS enzyme and/or the COX-2 enzyme;
- and
- (c) maintaining suppression of the iNOS enzyme or COX-2 enzyme until the cause of the chronic inflammation is removed or overcome.
Dependencies are inferred from the claim text.